Association between shiftwork and the risk of colorectal cancer in females: a population-based case-control study

Wa Mwenga Walasa, Renee N. Carey, Si Si, Lin Fritschi, Jane S. Heyworth, Renae C. Fernandez, Terry Boyle

Research output: Contribution to journalArticle

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Abstract

Objective Research indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case-control study. Graveyard shiftwork was the primary exposure of interest.

Methods Participants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.

Results Working in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.

Conclusions No evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

Original languageEnglish
Pages (from-to)344-350
Number of pages7
JournalOccupational and Environmental Medicine
Volume75
Issue number5
DOIs
Publication statusPublished - May 2018

Cite this

Walasa, Wa Mwenga ; Carey, Renee N. ; Si, Si ; Fritschi, Lin ; Heyworth, Jane S. ; Fernandez, Renae C. ; Boyle, Terry. / Association between shiftwork and the risk of colorectal cancer in females : a population-based case-control study. In: Occupational and Environmental Medicine. 2018 ; Vol. 75, No. 5. pp. 344-350.
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title = "Association between shiftwork and the risk of colorectal cancer in females: a population-based case-control study",
abstract = "Objective Research indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case-control study. Graveyard shiftwork was the primary exposure of interest.Methods Participants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95{\%} confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.Results Working in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95{\%} CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.Conclusions No evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.",
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Association between shiftwork and the risk of colorectal cancer in females : a population-based case-control study. / Walasa, Wa Mwenga; Carey, Renee N.; Si, Si; Fritschi, Lin; Heyworth, Jane S.; Fernandez, Renae C.; Boyle, Terry.

In: Occupational and Environmental Medicine, Vol. 75, No. 5, 05.2018, p. 344-350.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between shiftwork and the risk of colorectal cancer in females

T2 - a population-based case-control study

AU - Walasa, Wa Mwenga

AU - Carey, Renee N.

AU - Si, Si

AU - Fritschi, Lin

AU - Heyworth, Jane S.

AU - Fernandez, Renae C.

AU - Boyle, Terry

PY - 2018/5

Y1 - 2018/5

N2 - Objective Research indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case-control study. Graveyard shiftwork was the primary exposure of interest.Methods Participants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.Results Working in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.Conclusions No evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

AB - Objective Research indicates that shiftwork may be associated with increased risks of adverse health outcomes, including some cancers. However, the evidence of an association between shiftwork and colorectal cancer risk is limited and inconclusive. Further, while several possible pathways through which shiftwork might result in cancer have been proposed, few studies have taken these factors into account. We investigated the association between two types of shiftwork (graveyard shiftwork and early-morning shiftwork) and six mechanistic shiftwork variables (including light at night and phase shift) and the risk of colorectal cancer among females in an Australian population-based case-control study. Graveyard shiftwork was the primary exposure of interest.Methods Participants (350 cases and 410 controls) completed a lifetime occupational history, and exposure to each of the eight shiftwork variables was assigned to participants through a job exposure matrix. We used logistic regression to calculate odds ratios (OR) and corresponding 95% confidence intervals (CI) for the association between different shiftwork variables and the risk of colorectal cancer, adjusting for potential demographic, lifestyle and medical confounders.Results Working in an occupation involving long-term exposure (>7.5 years) to graveyard shiftwork was not associated with colorectal cancer risk (adjusted OR 0.95, 95% CI 0.57 to 1.58). Similarly, no increased risks of colorectal cancer were seen for any of the other seven shiftwork variables examined.Conclusions No evidence of an increased risk of colorectal cancer among females who had worked in occupations involving shiftwork was observed in this study.

KW - NIGHT-SHIFT

KW - BREAST-CANCER

KW - NURSES HEALTH

KW - WORK

KW - METAANALYSIS

KW - MECHANISMS

KW - ADENOMA

KW - SLEEP

KW - WOMEN

KW - MEN

U2 - 10.1136/oemed-2017-104657

DO - 10.1136/oemed-2017-104657

M3 - Article

VL - 75

SP - 344

EP - 350

JO - OEM Online

JF - OEM Online

SN - 1351-0711

IS - 5

ER -