Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children: a whole-of-population-based cohort study

Nusrat Homaira, Nancy Briggs, Christopher Pardy, Mark Hanly, Ju-Lee Oei, Lisa Hilder, Barbara Bajuk, Kei Lui, William Rawlinson, Tom Snelling, Adam Jaffe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective To determine the contribution of respiratory syncytial virus (RSV) to the subsequent development of severe asthma in different subgroups of children at risk of severe RSV disease.

Settings The study was conducted in New South Wales (NSW), Australia.

Participants The study comprised all children born in NSW between 2000 and 2010 with complete follow-up till 31 December 2011. The cohort was divided into three subgroups: (1) non-Indigenous high-risk children: non-Indigenous children born preterm or born with a low birth weight; (2) Indigenous children: children of mothers whose Indigenous status was recorded as Aboriginal and/or Torres Strait Islander and (3) non-Indigenous standard risk children: all other non-Indigenous term children.

Primary outcome measure Risk of development of severe asthma in different subgroups of children who had RSV hospitalisation in the first 2 years of life compared with those who did not.

Design We performed a retrospective cohort analysis using population-based linked administrative data. Extended Cox model was used to determine HR and 95% CI around the HR for first asthma hospitalisation in different subgroups of children.

Results The cohort comprised 847 516 children born between 2000 and 2010. In the adjusted Cox model, the HR of first asthma hospitalisation was higher and comparable across all subgroups of children who had RSV hospitalisation compared with those who did not. The HR (95% CI) was highest in children aged 2-3 years; 4.3 (95% CI 3.8 to 4.9) for high-risk, 4.0 (95% CI 3.3 to 4.8) for Indigenous and 3.9 (95% CI 3.7 to 4.1) for non-Indigenous standard risk children. This risk persisted beyond 7 years of age.

Conclusion This large study confirms a comparable increased risk of first asthma hospitalisation following RSV disease in the first 2 years of life across different subgroups children at risk.

Original languageEnglish
Article number017936
Number of pages6
JournalBMJ (Open)
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 2017

Cite this

Homaira, Nusrat ; Briggs, Nancy ; Pardy, Christopher ; Hanly, Mark ; Oei, Ju-Lee ; Hilder, Lisa ; Bajuk, Barbara ; Lui, Kei ; Rawlinson, William ; Snelling, Tom ; Jaffe, Adam. / Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children : a whole-of-population-based cohort study. In: BMJ (Open). 2017 ; Vol. 7, No. 11.
@article{c8e14dc054674948b030e192f83cbd79,
title = "Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children: a whole-of-population-based cohort study",
abstract = "Objective To determine the contribution of respiratory syncytial virus (RSV) to the subsequent development of severe asthma in different subgroups of children at risk of severe RSV disease.Settings The study was conducted in New South Wales (NSW), Australia.Participants The study comprised all children born in NSW between 2000 and 2010 with complete follow-up till 31 December 2011. The cohort was divided into three subgroups: (1) non-Indigenous high-risk children: non-Indigenous children born preterm or born with a low birth weight; (2) Indigenous children: children of mothers whose Indigenous status was recorded as Aboriginal and/or Torres Strait Islander and (3) non-Indigenous standard risk children: all other non-Indigenous term children.Primary outcome measure Risk of development of severe asthma in different subgroups of children who had RSV hospitalisation in the first 2 years of life compared with those who did not.Design We performed a retrospective cohort analysis using population-based linked administrative data. Extended Cox model was used to determine HR and 95{\%} CI around the HR for first asthma hospitalisation in different subgroups of children.Results The cohort comprised 847 516 children born between 2000 and 2010. In the adjusted Cox model, the HR of first asthma hospitalisation was higher and comparable across all subgroups of children who had RSV hospitalisation compared with those who did not. The HR (95{\%} CI) was highest in children aged 2-3 years; 4.3 (95{\%} CI 3.8 to 4.9) for high-risk, 4.0 (95{\%} CI 3.3 to 4.8) for Indigenous and 3.9 (95{\%} CI 3.7 to 4.1) for non-Indigenous standard risk children. This risk persisted beyond 7 years of age.Conclusion This large study confirms a comparable increased risk of first asthma hospitalisation following RSV disease in the first 2 years of life across different subgroups children at risk.",
keywords = "RSV BRONCHIOLITIS, VIRUS-INFECTION, PALIVIZUMAB PROPHYLAXIS, YOUNG-CHILDREN, EARLY-LIFE, ATOPY, HOSPITALIZATION, WHEEZE, AGE, SENSITIZATION",
author = "Nusrat Homaira and Nancy Briggs and Christopher Pardy and Mark Hanly and Ju-Lee Oei and Lisa Hilder and Barbara Bajuk and Kei Lui and William Rawlinson and Tom Snelling and Adam Jaffe",
year = "2017",
month = "11",
doi = "10.1136/bmjopen-2017-017936",
language = "English",
volume = "7",
journal = "BMJ (Open)",
issn = "2044-6055",
publisher = "John Wiley & Sons",
number = "11",

}

Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children : a whole-of-population-based cohort study. / Homaira, Nusrat; Briggs, Nancy; Pardy, Christopher; Hanly, Mark; Oei, Ju-Lee; Hilder, Lisa; Bajuk, Barbara; Lui, Kei; Rawlinson, William; Snelling, Tom; Jaffe, Adam.

In: BMJ (Open), Vol. 7, No. 11, 017936, 11.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between respiratory syncytial viral disease and the subsequent risk of the first episode of severe asthma in different subgroups of high-risk Australian children

T2 - a whole-of-population-based cohort study

AU - Homaira, Nusrat

AU - Briggs, Nancy

AU - Pardy, Christopher

AU - Hanly, Mark

AU - Oei, Ju-Lee

AU - Hilder, Lisa

AU - Bajuk, Barbara

AU - Lui, Kei

AU - Rawlinson, William

AU - Snelling, Tom

AU - Jaffe, Adam

PY - 2017/11

Y1 - 2017/11

N2 - Objective To determine the contribution of respiratory syncytial virus (RSV) to the subsequent development of severe asthma in different subgroups of children at risk of severe RSV disease.Settings The study was conducted in New South Wales (NSW), Australia.Participants The study comprised all children born in NSW between 2000 and 2010 with complete follow-up till 31 December 2011. The cohort was divided into three subgroups: (1) non-Indigenous high-risk children: non-Indigenous children born preterm or born with a low birth weight; (2) Indigenous children: children of mothers whose Indigenous status was recorded as Aboriginal and/or Torres Strait Islander and (3) non-Indigenous standard risk children: all other non-Indigenous term children.Primary outcome measure Risk of development of severe asthma in different subgroups of children who had RSV hospitalisation in the first 2 years of life compared with those who did not.Design We performed a retrospective cohort analysis using population-based linked administrative data. Extended Cox model was used to determine HR and 95% CI around the HR for first asthma hospitalisation in different subgroups of children.Results The cohort comprised 847 516 children born between 2000 and 2010. In the adjusted Cox model, the HR of first asthma hospitalisation was higher and comparable across all subgroups of children who had RSV hospitalisation compared with those who did not. The HR (95% CI) was highest in children aged 2-3 years; 4.3 (95% CI 3.8 to 4.9) for high-risk, 4.0 (95% CI 3.3 to 4.8) for Indigenous and 3.9 (95% CI 3.7 to 4.1) for non-Indigenous standard risk children. This risk persisted beyond 7 years of age.Conclusion This large study confirms a comparable increased risk of first asthma hospitalisation following RSV disease in the first 2 years of life across different subgroups children at risk.

AB - Objective To determine the contribution of respiratory syncytial virus (RSV) to the subsequent development of severe asthma in different subgroups of children at risk of severe RSV disease.Settings The study was conducted in New South Wales (NSW), Australia.Participants The study comprised all children born in NSW between 2000 and 2010 with complete follow-up till 31 December 2011. The cohort was divided into three subgroups: (1) non-Indigenous high-risk children: non-Indigenous children born preterm or born with a low birth weight; (2) Indigenous children: children of mothers whose Indigenous status was recorded as Aboriginal and/or Torres Strait Islander and (3) non-Indigenous standard risk children: all other non-Indigenous term children.Primary outcome measure Risk of development of severe asthma in different subgroups of children who had RSV hospitalisation in the first 2 years of life compared with those who did not.Design We performed a retrospective cohort analysis using population-based linked administrative data. Extended Cox model was used to determine HR and 95% CI around the HR for first asthma hospitalisation in different subgroups of children.Results The cohort comprised 847 516 children born between 2000 and 2010. In the adjusted Cox model, the HR of first asthma hospitalisation was higher and comparable across all subgroups of children who had RSV hospitalisation compared with those who did not. The HR (95% CI) was highest in children aged 2-3 years; 4.3 (95% CI 3.8 to 4.9) for high-risk, 4.0 (95% CI 3.3 to 4.8) for Indigenous and 3.9 (95% CI 3.7 to 4.1) for non-Indigenous standard risk children. This risk persisted beyond 7 years of age.Conclusion This large study confirms a comparable increased risk of first asthma hospitalisation following RSV disease in the first 2 years of life across different subgroups children at risk.

KW - RSV BRONCHIOLITIS

KW - VIRUS-INFECTION

KW - PALIVIZUMAB PROPHYLAXIS

KW - YOUNG-CHILDREN

KW - EARLY-LIFE

KW - ATOPY

KW - HOSPITALIZATION

KW - WHEEZE

KW - AGE

KW - SENSITIZATION

U2 - 10.1136/bmjopen-2017-017936

DO - 10.1136/bmjopen-2017-017936

M3 - Article

VL - 7

JO - BMJ (Open)

JF - BMJ (Open)

SN - 2044-6055

IS - 11

M1 - 017936

ER -