Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma

L.M. Stewart, C.J.R. Stewart, K. Spilsbury, P.A. Cohen, Susan Jordan

Research output: Contribution to journalArticle

Abstract

Objective. Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderline
tumor (SBT), mucinous borderline tumor (MBT) and LGSC.
Methods. This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios (HRs).
Results.We observed an increased rate of SBT associated with infertility, PID and ectopic pregnancy (HRs and 95% CIs were, respectively, 1.98 (1.20–3.26); 1.95 (1.22–3.10) and 2.44 (1.20–4.96)).We did not detect an association between any of the factors under study and the rate of MBT. A diagnosis of PID was associated with an
increased rate of LGSC (HR 2.90, 95% CI 1.21–6.94).
Conclusions. The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC.
Original languageEnglish
JournalGynecologic Oncology
DOIs
Publication statusE-pub ahead of print - 23 Jan 2020

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Pelvic Inflammatory Disease
Ectopic Pregnancy
Infertility
Carcinoma
Neoplasms
Tubal Sterilization
Western Australia
Peritoneum
Endometriosis
Parity
Hysterectomy
Cohort Studies
Population

Cite this

@article{174f9bd2223748d1a0ccf6ad20284217,
title = "Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma",
abstract = "Objective. Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderlinetumor (SBT), mucinous borderline tumor (MBT) and LGSC.Methods. This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios (HRs).Results.We observed an increased rate of SBT associated with infertility, PID and ectopic pregnancy (HRs and 95{\%} CIs were, respectively, 1.98 (1.20–3.26); 1.95 (1.22–3.10) and 2.44 (1.20–4.96)).We did not detect an association between any of the factors under study and the rate of MBT. A diagnosis of PID was associated with anincreased rate of LGSC (HR 2.90, 95{\%} CI 1.21–6.94).Conclusions. The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC.",
author = "L.M. Stewart and C.J.R. Stewart and K. Spilsbury and P.A. Cohen and Susan Jordan",
year = "2020",
month = "1",
day = "23",
doi = "10.1016/j.ygyno.2020.01.027",
language = "English",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press",

}

TY - JOUR

T1 - Association between pelvic inflammatory disease, infertility, ectopic pregnancy and the development of ovarian serous borderline tumor, mucinous borderline tumor and low-grade serous carcinoma

AU - Stewart, L.M.

AU - Stewart, C.J.R.

AU - Spilsbury, K.

AU - Cohen, P.A.

AU - Jordan, Susan

PY - 2020/1/23

Y1 - 2020/1/23

N2 - Objective. Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderlinetumor (SBT), mucinous borderline tumor (MBT) and LGSC.Methods. This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios (HRs).Results.We observed an increased rate of SBT associated with infertility, PID and ectopic pregnancy (HRs and 95% CIs were, respectively, 1.98 (1.20–3.26); 1.95 (1.22–3.10) and 2.44 (1.20–4.96)).We did not detect an association between any of the factors under study and the rate of MBT. A diagnosis of PID was associated with anincreased rate of LGSC (HR 2.90, 95% CI 1.21–6.94).Conclusions. The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC.

AB - Objective. Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderlinetumor (SBT), mucinous borderline tumor (MBT) and LGSC.Methods. This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios (HRs).Results.We observed an increased rate of SBT associated with infertility, PID and ectopic pregnancy (HRs and 95% CIs were, respectively, 1.98 (1.20–3.26); 1.95 (1.22–3.10) and 2.44 (1.20–4.96)).We did not detect an association between any of the factors under study and the rate of MBT. A diagnosis of PID was associated with anincreased rate of LGSC (HR 2.90, 95% CI 1.21–6.94).Conclusions. The association with PID supports the hypothesis that inflammatory processes within the upper gynaecological tract and/or peritoneum may predispose to the development of SBT and LGSC.

U2 - 10.1016/j.ygyno.2020.01.027

DO - 10.1016/j.ygyno.2020.01.027

M3 - Article

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

ER -