Association Between Paternally Inherited Haplotypes Upstream of the Insulin Gene and Umbilical Cord IGF-II Levels

R.M. Adkins, J.N. Fain, J. Krushkal, C.K. Klauser, Pat Magann, J.C. Morrison

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    6 Citations (Scopus)

    Abstract

    The insulin (INS) and IGF 2 (IGF2) genes are in close proximity to each other and undergo maternal imprinting during fetal growth. We investigated the association between maternal and umbilical cord IGF 2 protein (IGF-II) levels and single nucleotide polymorphisms (SNPs) in the INS and IGF2 genes in 207 healthy African-American mother-newborn pairs. No association was found between maternal IGF-II levels and polymorphism in the INS-IGF2 locus. A significant association was found between newborn IGF-II levels and two SNPs (rs3842738 and rs689) at the 5' end of the INS-IGF2 focus. Analyses of haplotypes inferred from these two SNPs demonstrate a significant relationship between paternally transmitted haplotypes and newborn IGF-II levels, but no association with maternally transmitted haplotypes.
    Original languageEnglish
    Pages (from-to)451-455
    JournalPediatric Research
    Volume62
    Issue number4
    DOIs
    Publication statusPublished - 2007

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