Projects per year
Abstract
OBJECTIVE: To examine the association between high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, muscle function decline and 14.5-year fall-related hospitalisation risk in women aged over 70 years. METHODS: 1179 ambulatory community-dwelling women aged over 70 years with subclinical levels of hs-cTnI (ie, <15.6 ng/L), who were followed up for 14.5 years, were included. Samples for hs-cTnI were obtained in 1998. Fall-related hospitalisations were retrieved from linked health records. Muscle function measures, including handgrip strength and the Timed-Up-and-Go (TUG) test, were assessed in 1998 and 2003. RESULTS: Mean±SD age was 75.2±2.7 years. Over 14.5 years of follow-up, 40.4% (476 of 1179) experienced fall-related hospitalisation. Participants were categorised into four approximate hs-cTnI quartiles: quartile 1 (<3.6 ng/L), quartile 2 (3.6-4.4 ng/L), quartile 3 (4.5-5.8 ng/L) and quartile 4 (≥5.9 ng/L). Compared with those in Q1, women in Q4 were likely to experience fall-related hospitalisation (36.0% vs 42.8%). In a multivariable-adjusted model that accounted for CVD and fall risk factors, compared with women in Q1, those in Q4 had a 46% higher risk of fall-related hospitalisation (HR 1.46, 95% CI 1.08 to 1.98). Additionally, women in Q4 had slower TUG performance compared with those in Q1 (10.3 s vs 9.5 s, p=0.032). CONCLUSION: Elevated level of hs-cTnI was associated with slower TUG performance and increased fall-related hospitalisation risk. This indicates subclinical level of hs-cTnI can identify clinically relevant falls, emphasising the need to consider cardiac health during fall assessment in women aged over 70 years. TRIAL REGISTRATION NUMBER: ACTRN12617000640303.
Original language | English |
---|---|
Pages (from-to) | 108-114 |
Number of pages | 7 |
Journal | Heart (British Cardiac Society) |
Volume | 110 |
Issue number | 2 |
DOIs | |
Publication status | Published - 3 Aug 2023 |
Fingerprint
Dive into the research topics of 'Association between high-sensitivity cardiac troponin I and fall-related hospitalisation in women aged over 70 years'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Determinants of Musculoskeletal and Other Diseases, Health Service Utilisation and Mortality in a Cohort of Older Women
Zhu, K. (Investigator 01), Prince, R. (Investigator 02), Flicker, L. (Investigator 03) & Mukhtar, S. (Investigator 04)
NHMRC National Health and Medical Research Council
31/12/08 → 31/12/13
Project: Research
-
Environmental and Metabolic Influences on Musculoskeletal and other Diseases in a Cohort of Elderly Women
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Thompson, P. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/04 → 31/12/08
Project: Research
-
Extension of the Calcium Intake Fracture Outcome Study
Prince, R. (Chief Investigator), Devine, A. (Chief Investigator), Dhaliwal, S. S. (Chief Investigator) & Dick, I. (Chief Investigator)
1/01/03 → 31/12/04
Project: Research