Association between focal lamina cribrosa defects and optic disc haemorrhage in glaucoma

Vijay Mistry, Dong An, Christopher J. Barry, Philip H. House, William H. Morgan

Research output: Contribution to journalArticle

Abstract

Background/aims: To explore the relationship between focal lamina defect (LD) size and optic disc haemorrhages (DH) in glaucomatous eyes. Methods: Radial B-scan images at 15° intervals obtained using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT) were performed on a group of subjects previously assessed for DH every 3 months over a period of 5 years. EDI-OCT scans were assessed for the presence of focal lamina cribrosa defects by a single observer. Results: 119 eyes from 62 subjects (44 females, 18 males) were analysed. 44 eyes (37%) were noted to have at least 1 LD, and of those, eight eyes had more than one defect. 68 eyes (57%) were observed to have at least one DH occur over the course of monitoring. 48 eyes (40%) had recurrent DH, with a mean of 5.17 haemorrhages over the 5-year period. Type 1 focal LD (p=0.0000, OR 7.17), glaucoma progression (p=0.0024, OR 0.32) and ArtDiff (p=0.0466, OR 1.04) were significantly associated as predictors of DH. No correlation between the size of the LD and DH occurrence (p=0.6449, Spearman rank correlation) was found. Conclusion: Focal lamina cribrosa hole-type defects were significantly associated with an increase in DH occurrence over the preceding 5 years. The lack of association between defect size and DH suggests that DH and lamina defects may have separate links to the glaucomatous process.

Original languageEnglish
JournalBritish Journal of Ophthalmology
DOIs
Publication statusE-pub ahead of print - 25 Apr 2019

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Optic Disk
Glaucoma
Hemorrhage
Optical Coherence Tomography

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title = "Association between focal lamina cribrosa defects and optic disc haemorrhage in glaucoma",
abstract = "Background/aims: To explore the relationship between focal lamina defect (LD) size and optic disc haemorrhages (DH) in glaucomatous eyes. Methods: Radial B-scan images at 15° intervals obtained using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT) were performed on a group of subjects previously assessed for DH every 3 months over a period of 5 years. EDI-OCT scans were assessed for the presence of focal lamina cribrosa defects by a single observer. Results: 119 eyes from 62 subjects (44 females, 18 males) were analysed. 44 eyes (37{\%}) were noted to have at least 1 LD, and of those, eight eyes had more than one defect. 68 eyes (57{\%}) were observed to have at least one DH occur over the course of monitoring. 48 eyes (40{\%}) had recurrent DH, with a mean of 5.17 haemorrhages over the 5-year period. Type 1 focal LD (p=0.0000, OR 7.17), glaucoma progression (p=0.0024, OR 0.32) and ArtDiff (p=0.0466, OR 1.04) were significantly associated as predictors of DH. No correlation between the size of the LD and DH occurrence (p=0.6449, Spearman rank correlation) was found. Conclusion: Focal lamina cribrosa hole-type defects were significantly associated with an increase in DH occurrence over the preceding 5 years. The lack of association between defect size and DH suggests that DH and lamina defects may have separate links to the glaucomatous process.",
keywords = "glaucoma, lamina cribrosa, lamina defects, optic disc haemorrhage",
author = "Vijay Mistry and Dong An and Barry, {Christopher J.} and House, {Philip H.} and Morgan, {William H.}",
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Association between focal lamina cribrosa defects and optic disc haemorrhage in glaucoma. / Mistry, Vijay; An, Dong; Barry, Christopher J.; House, Philip H.; Morgan, William H.

In: British Journal of Ophthalmology, 25.04.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between focal lamina cribrosa defects and optic disc haemorrhage in glaucoma

AU - Mistry, Vijay

AU - An, Dong

AU - Barry, Christopher J.

AU - House, Philip H.

AU - Morgan, William H.

PY - 2019/4/25

Y1 - 2019/4/25

N2 - Background/aims: To explore the relationship between focal lamina defect (LD) size and optic disc haemorrhages (DH) in glaucomatous eyes. Methods: Radial B-scan images at 15° intervals obtained using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT) were performed on a group of subjects previously assessed for DH every 3 months over a period of 5 years. EDI-OCT scans were assessed for the presence of focal lamina cribrosa defects by a single observer. Results: 119 eyes from 62 subjects (44 females, 18 males) were analysed. 44 eyes (37%) were noted to have at least 1 LD, and of those, eight eyes had more than one defect. 68 eyes (57%) were observed to have at least one DH occur over the course of monitoring. 48 eyes (40%) had recurrent DH, with a mean of 5.17 haemorrhages over the 5-year period. Type 1 focal LD (p=0.0000, OR 7.17), glaucoma progression (p=0.0024, OR 0.32) and ArtDiff (p=0.0466, OR 1.04) were significantly associated as predictors of DH. No correlation between the size of the LD and DH occurrence (p=0.6449, Spearman rank correlation) was found. Conclusion: Focal lamina cribrosa hole-type defects were significantly associated with an increase in DH occurrence over the preceding 5 years. The lack of association between defect size and DH suggests that DH and lamina defects may have separate links to the glaucomatous process.

AB - Background/aims: To explore the relationship between focal lamina defect (LD) size and optic disc haemorrhages (DH) in glaucomatous eyes. Methods: Radial B-scan images at 15° intervals obtained using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (OCT) were performed on a group of subjects previously assessed for DH every 3 months over a period of 5 years. EDI-OCT scans were assessed for the presence of focal lamina cribrosa defects by a single observer. Results: 119 eyes from 62 subjects (44 females, 18 males) were analysed. 44 eyes (37%) were noted to have at least 1 LD, and of those, eight eyes had more than one defect. 68 eyes (57%) were observed to have at least one DH occur over the course of monitoring. 48 eyes (40%) had recurrent DH, with a mean of 5.17 haemorrhages over the 5-year period. Type 1 focal LD (p=0.0000, OR 7.17), glaucoma progression (p=0.0024, OR 0.32) and ArtDiff (p=0.0466, OR 1.04) were significantly associated as predictors of DH. No correlation between the size of the LD and DH occurrence (p=0.6449, Spearman rank correlation) was found. Conclusion: Focal lamina cribrosa hole-type defects were significantly associated with an increase in DH occurrence over the preceding 5 years. The lack of association between defect size and DH suggests that DH and lamina defects may have separate links to the glaucomatous process.

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KW - lamina cribrosa

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KW - optic disc haemorrhage

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DO - 10.1136/bjophthalmol-2018-313775

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JO - British Journal of Opthalmology

JF - British Journal of Opthalmology

SN - 0007-1161

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