Projects per year
Abstract
Background: Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. Methods: Infants with CF were enrolled before 4 months of age. Multiplex PCR assays were performed on nasal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent CT imaging at approximately 12 months of age. Associations between Perth–Rotterdam Annotated Grid Morphometric Analysis for CF (PRAGMA-CF) CT scores and respiratory viruses and symptoms were assessed with Spearman correlation coefficients. Results: Sixty infants were included for analysis. Human rhinovirus was the most common virus detected, on 28% of tested nasal swabs and in 85% of participants. The median (IQR) extent of lung fields that was healthy based on PRAGMA-CF was 98.7 (0.8)%. There were no associations between PRAGMA-CF and age at first virus, or detection of any virus, including rhinovirus, respiratory syncytial virus, or parainfluenza. The extent of airway wall thickening was associated with ever having wheezed (ρ = 0.31, p = 0.02) and number of encounters with cough (ρ = 0.25, p = 0.0495). Conclusions: Infants with CF had minimal structural lung disease. We did not find an association between respiratory viruses and CT abnormalities. Wheezing and frequency of cough were associated with early structural changes.
Original language | English |
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Pages (from-to) | 1020-1026 |
Number of pages | 7 |
Journal | Journal of Cystic Fibrosis |
Volume | 21 |
Issue number | 6 |
DOIs | |
Publication status | Published - Nov 2022 |
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Dive into the research topics of 'Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis'. Together they form a unique fingerprint.Projects
- 3 Finished
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Role of Viruses in the Development of Lung Disease in Cystic Fibrosis
Ranganathan, S. (Investigator 01) & Hall, G. (Investigator 02)
NHMRC National Health and Medical Research Council
1/01/13 → 31/12/17
Project: Research
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NHMRC Career Development Fellowships - Hall
Hall, G. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/12 → 31/12/15
Project: Research
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The Centre for Research in Childhood Early Respiratory Disease
Stick, S. (Investigator 01), Sly, P. (Investigator 02), Ranganathan, S. (Investigator 03), Robinson, P. (Investigator 04), Robertson, C. (Investigator 05), Hall, G. (Investigator 06), De Klerk, N. (Investigator 07), Robins-Browne, R. (Investigator 08) & Shields, L. (Investigator 09)
NHMRC National Health and Medical Research Council
1/01/10 → 31/12/15
Project: Research