Projects per year
Abstract
Background: Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. Materials and Methods: Men (n = 20) and women (n = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed. Results: Following the HK diet, ucOC and ucOC/tOC were suppressed more (p < 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (p > 0.05). Discussion/Conclusion: Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.
Original language | English |
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Pages (from-to) | 361-367 |
Number of pages | 7 |
Journal | ANNALS OF NUTRITION AND METABOLISM |
Volume | 76 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jan 2021 |
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Dive into the research topics of 'Association between Circulating Osteocalcin and Cardiometabolic Risk Factors following a 4-Week Leafy Green Vitamin K-Rich Diet'. Together they form a unique fingerprint.Projects
- 2 Curtailed
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Dietary approaches to enhance vascular health
Hodgson, J. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/17 → 9/10/20
Project: Research
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Consumption of nitrate-rich vegetables to reduce blood pressure
Hodgson, J. (Investigator 01), Beilin, L. (Investigator 02), Prince, R. (Investigator 03) & Woodman, R. (Investigator 04)
NHMRC National Health and Medical Research Council
1/01/15 → 30/12/17
Project: Research