Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

F. Wensley; P. Gao; S. Burgess; S. Kaptoge; E. Di Angelantonio; T. Shah; J.C. Engert; R. Clarke; G. Davey-Smith; B.G. Nordestgaard; D. Saleheen; N.J. Samani; M. Sandhu; S. Anand; M.B. Pepys; L. Smeeth; J. Whittaker; J.P. Casas; S.G. Thompson; A.D. Hingorani; J. Danesh; G. Eiriksdottir; T.B. Harris; L.J. Launer; V. Gudnason; A.R. Folsom; G. Andrews; C.M. Ballantyne; A.S. Hall; P.S. Braund; A.J. Balmforth; P.H. Whincup; R. Morris; D.A. Lawlor; G.D.O. Lowe; N. Timpson; S. Ebrahim; Y. Ben-Shlomo; A. Tybjaerg-Hansen; J. Zacho; M. Brown; S.L. Ricketts; S. Ashford; L. Lange; A. Reiner; M. Cushman; R. Tracy; C. Wu; J. Ge; Y. Zou; A. Sun; Joe Hung; Brendan Mcquillan; P. Thompson; J. Beilby; Nicole Warrington; L.J. Palmer; C. Wanner; C. Drechsler; M.M. Hoffmann; F.G.R. Fowkes; I. Tzoulaki; M. Kumari; M. Miller; M. Marmot; C. Onland-Moret; Y.T. Van Der Schouw; J.M. Boer; C. Wijmenga; L. Ricketts; K.T. Khaw; R.S. Vasan; R.B. Schnabel; J.F. Yamamoto; E.J. Benjamin; H. Schunkert; J. Erdmann; I.R. Koenig; C. Hengstenberg; B. Chiodini; M.G. Franzosi; S. Pietri; F. Gori; M. Rudock; Y. Liu; K. Lohman; S.E. Humphries; A. Hamsten; P.E. Norman; Graeme Hankey; K. Jamrozik; E.B. Rimm; J.K. Pai; B.M. Psaty; S.R. Heckbert; J.C. Bis; S. Yusuf; C. Xie; R. Collins; D. Bennett; J. Kooner; J. Chambers; P. Elliott; W. Maerz; M.E. Kleber; B.O. Boehm; B.R. Winkelmann; O. Melander; G. Berglund; W. Koenig; B. Thorand; J. Baumert; A. Peters; J. Manson; J.A. Cooper; P.J. Talmud; P. Ladenvall; L. Johansson; J.H. Jansson; G. Hallmans; M.P. Reilly; L. Qu; M. Li; D.J. Rader; H. Watkins; J. Hopewell; P. Frossard; N. Sattar; M. Robertson; J. Shepherd; E. Schaefer; A. Hofman; J.C.M. Witteman; I. Kardys; A. Dehghan; U. De Faire; A. Bennet; B. Gigante; K. Leander; B. Peters; A.H. Maitland-Van Der Zee; A. De Boer; O. Klungel; P. Greenland; J. Dai; S. Liu; E. Brunner; M. Kivimaki; D. O'Reilly; I. Ford; C.J. Packard

doi:10.1136/bmj.d548

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

F. Wensley, P. Gao, S. Burgess, S. Kaptoge, E. Di Angelantonio, T. Shah, J.C. Engert, R. Clarke, G. Davey-Smith, B.G. Nordestgaard, D. Saleheen, N.J. Samani, M. Sandhu, S. Anand, M.B. Pepys, L. Smeeth, J. Whittaker, J.P. Casas, S.G. Thompson, A.D. HingoraniJ. Danesh, G. Eiriksdottir, T.B. Harris, L.J. Launer, V. Gudnason, A.R. Folsom, G. Andrews, C.M. Ballantyne, A.S. Hall, P.S. Braund, A.J. Balmforth, P.H. Whincup, R. Morris, D.A. Lawlor, G.D.O. Lowe, N. Timpson, S. Ebrahim, Y. Ben-Shlomo, A. Tybjaerg-Hansen, J. Zacho, M. Brown, S.L. Ricketts, S. Ashford, L. Lange, A. Reiner, M. Cushman, R. Tracy, C. Wu, J. Ge, Y. Zou, A. Sun, Joe Hung, Brendan Mcquillan, P. Thompson, J. Beilby, Nicole Warrington, L.J. Palmer, C. Wanner, C. Drechsler, M.M. Hoffmann, F.G.R. Fowkes, I. Tzoulaki, M. Kumari, M. Miller, M. Marmot, C. Onland-Moret, Y.T. Van Der Schouw, J.M. Boer, C. Wijmenga, L. Ricketts, K.T. Khaw, R.S. Vasan, R.B. Schnabel, J.F. Yamamoto, E.J. Benjamin, H. Schunkert, J. Erdmann, I.R. Koenig, C. Hengstenberg, B. Chiodini, M.G. Franzosi, S. Pietri, F. Gori, M. Rudock, Y. Liu, K. Lohman, S.E. Humphries, A. Hamsten, P.E. Norman, Graeme Hankey, K. Jamrozik, E.B. Rimm, J.K. Pai, B.M. Psaty, S.R. Heckbert, J.C. Bis, S. Yusuf, C. Xie, R. Collins, D. Bennett, J. Kooner, J. Chambers, P. Elliott, W. Maerz, M.E. Kleber, B.O. Boehm, B.R. Winkelmann, O. Melander, G. Berglund, W. Koenig, B. Thorand, J. Baumert, A. Peters, J. Manson, J.A. Cooper, P.J. Talmud, P. Ladenvall, L. Johansson, J.H. Jansson, G. Hallmans, M.P. Reilly, L. Qu, M. Li, D.J. Rader, H. Watkins, J. Hopewell, P. Frossard, N. Sattar, M. Robertson, J. Shepherd, E. Schaefer, A. Hofman, J.C.M. Witteman, I. Kardys, A. Dehghan, U. De Faire, A. Bennet, B. Gigante, K. Leander, B. Peters, A.H. Maitland-Van Der Zee, A. De Boer, O. Klungel, P. Greenland, J. Dai, S. Liu, E. Brunner, M. Kivimaki, D. O'Reilly, I. Ford, C.J. Packard

Research output: Contribution to journal › Article

172 Citations (Scopus)

Abstract

Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein (P

Original language	English
Pages (from-to)	1-8
Journal	British Medical Journal
Volume	342
DOIs	https://doi.org/10.1136/bmj.d548
Publication status	Published - 2011

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10.1136/bmj.d548

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Wensley, F., Gao, P., Burgess, S., Kaptoge, S., Di Angelantonio, E., Shah, T., Engert, J. C., Clarke, R., Davey-Smith, G., Nordestgaard, B. G., Saleheen, D., Samani, N. J., Sandhu, M., Anand, S., Pepys, M. B., Smeeth, L., Whittaker, J., Casas, J. P., Thompson, S. G., ... Packard, C. J. (2011). Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. British Medical Journal, 342, 1-8. https://doi.org/10.1136/bmj.d548

Wensley, F. ; Gao, P. ; Burgess, S. ; Kaptoge, S. ; Di Angelantonio, E. ; Shah, T. ; Engert, J.C. ; Clarke, R. ; Davey-Smith, G. ; Nordestgaard, B.G. ; Saleheen, D. ; Samani, N.J. ; Sandhu, M. ; Anand, S. ; Pepys, M.B. ; Smeeth, L. ; Whittaker, J. ; Casas, J.P. ; Thompson, S.G. ; Hingorani, A.D. ; Danesh, J. ; Eiriksdottir, G. ; Harris, T.B. ; Launer, L.J. ; Gudnason, V. ; Folsom, A.R. ; Andrews, G. ; Ballantyne, C.M. ; Hall, A.S. ; Braund, P.S. ; Balmforth, A.J. ; Whincup, P.H. ; Morris, R. ; Lawlor, D.A. ; Lowe, G.D.O. ; Timpson, N. ; Ebrahim, S. ; Ben-Shlomo, Y. ; Tybjaerg-Hansen, A. ; Zacho, J. ; Brown, M. ; Ricketts, S.L. ; Ashford, S. ; Lange, L. ; Reiner, A. ; Cushman, M. ; Tracy, R. ; Wu, C. ; Ge, J. ; Zou, Y. ; Sun, A. ; Hung, Joe ; Mcquillan, Brendan ; Thompson, P. ; Beilby, J. ; Warrington, Nicole ; Palmer, L.J. ; Wanner, C. ; Drechsler, C. ; Hoffmann, M.M. ; Fowkes, F.G.R. ; Tzoulaki, I. ; Kumari, M. ; Miller, M. ; Marmot, M. ; Onland-Moret, C. ; Van Der Schouw, Y.T. ; Boer, J.M. ; Wijmenga, C. ; Ricketts, L. ; Khaw, K.T. ; Vasan, R.S. ; Schnabel, R.B. ; Yamamoto, J.F. ; Benjamin, E.J. ; Schunkert, H. ; Erdmann, J. ; Koenig, I.R. ; Hengstenberg, C. ; Chiodini, B. ; Franzosi, M.G. ; Pietri, S. ; Gori, F. ; Rudock, M. ; Liu, Y. ; Lohman, K. ; Humphries, S.E. ; Hamsten, A. ; Norman, P.E. ; Hankey, Graeme ; Jamrozik, K. ; Rimm, E.B. ; Pai, J.K. ; Psaty, B.M. ; Heckbert, S.R. ; Bis, J.C. ; Yusuf, S. ; Xie, C. ; Collins, R. ; Bennett, D. ; Kooner, J. ; Chambers, J. ; Elliott, P. ; Maerz, W. ; Kleber, M.E. ; Boehm, B.O. ; Winkelmann, B.R. ; Melander, O. ; Berglund, G. ; Koenig, W. ; Thorand, B. ; Baumert, J. ; Peters, A. ; Manson, J. ; Cooper, J.A. ; Talmud, P.J. ; Ladenvall, P. ; Johansson, L. ; Jansson, J.H. ; Hallmans, G. ; Reilly, M.P. ; Qu, L. ; Li, M. ; Rader, D.J. ; Watkins, H. ; Hopewell, J. ; Frossard, P. ; Sattar, N. ; Robertson, M. ; Shepherd, J. ; Schaefer, E. ; Hofman, A. ; Witteman, J.C.M. ; Kardys, I. ; Dehghan, A. ; De Faire, U. ; Bennet, A. ; Gigante, B. ; Leander, K. ; Peters, B. ; Maitland-Van Der Zee, A.H. ; De Boer, A. ; Klungel, O. ; Greenland, P. ; Dai, J. ; Liu, S. ; Brunner, E. ; Kivimaki, M. ; O'Reilly, D. ; Ford, I. ; Packard, C.J. / Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. In: British Medical Journal. 2011 ; Vol. 342. pp. 1-8.

@article{229e9c0a9e6d4c0abf879a4c7dedfdb9,

title = "Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data",

abstract = "Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein (P",

author = "F. Wensley and P. Gao and S. Burgess and S. Kaptoge and {Di Angelantonio}, E. and T. Shah and J.C. Engert and R. Clarke and G. Davey-Smith and B.G. Nordestgaard and D. Saleheen and N.J. Samani and M. Sandhu and S. Anand and M.B. Pepys and L. Smeeth and J. Whittaker and J.P. Casas and S.G. Thompson and A.D. Hingorani and J. Danesh and G. Eiriksdottir and T.B. Harris and L.J. Launer and V. Gudnason and A.R. Folsom and G. Andrews and C.M. Ballantyne and A.S. Hall and P.S. Braund and A.J. Balmforth and P.H. Whincup and R. Morris and D.A. Lawlor and G.D.O. Lowe and N. Timpson and S. Ebrahim and Y. Ben-Shlomo and A. Tybjaerg-Hansen and J. Zacho and M. Brown and S.L. Ricketts and S. Ashford and L. Lange and A. Reiner and M. Cushman and R. Tracy and C. Wu and J. Ge and Y. Zou and A. Sun and Joe Hung and Brendan Mcquillan and P. Thompson and J. Beilby and Nicole Warrington and L.J. Palmer and C. Wanner and C. Drechsler and M.M. Hoffmann and F.G.R. Fowkes and I. Tzoulaki and M. Kumari and M. Miller and M. Marmot and C. Onland-Moret and {Van Der Schouw}, Y.T. and J.M. Boer and C. Wijmenga and L. Ricketts and K.T. Khaw and R.S. Vasan and R.B. Schnabel and J.F. Yamamoto and E.J. Benjamin and H. Schunkert and J. Erdmann and I.R. Koenig and C. Hengstenberg and B. Chiodini and M.G. Franzosi and S. Pietri and F. Gori and M. Rudock and Y. Liu and K. Lohman and S.E. Humphries and A. Hamsten and P.E. Norman and Graeme Hankey and K. Jamrozik and E.B. Rimm and J.K. Pai and B.M. Psaty and S.R. Heckbert and J.C. Bis and S. Yusuf and C. Xie and R. Collins and D. Bennett and J. Kooner and J. Chambers and P. Elliott and W. Maerz and M.E. Kleber and B.O. Boehm and B.R. Winkelmann and O. Melander and G. Berglund and W. Koenig and B. Thorand and J. Baumert and A. Peters and J. Manson and J.A. Cooper and P.J. Talmud and P. Ladenvall and L. Johansson and J.H. Jansson and G. Hallmans and M.P. Reilly and L. Qu and M. Li and D.J. Rader and H. Watkins and J. Hopewell and P. Frossard and N. Sattar and M. Robertson and J. Shepherd and E. Schaefer and A. Hofman and J.C.M. Witteman and I. Kardys and A. Dehghan and {De Faire}, U. and A. Bennet and B. Gigante and K. Leander and B. Peters and {Maitland-Van Der Zee}, A.H. and {De Boer}, A. and O. Klungel and P. Greenland and J. Dai and S. Liu and E. Brunner and M. Kivimaki and D. O'Reilly and I. Ford and C.J. Packard",

year = "2011",

doi = "10.1136/bmj.d548",

language = "English",

volume = "342",

pages = "1--8",

journal = "BMJ: British Medical Journal",

issn = "0959-535X",

publisher = "BMJ Publishing Group",

}

Wensley, F, Gao, P, Burgess, S, Kaptoge, S, Di Angelantonio, E, Shah, T, Engert, JC, Clarke, R, Davey-Smith, G, Nordestgaard, BG, Saleheen, D, Samani, NJ, Sandhu, M, Anand, S, Pepys, MB, Smeeth, L, Whittaker, J, Casas, JP, Thompson, SG, Hingorani, AD, Danesh, J, Eiriksdottir, G, Harris, TB, Launer, LJ, Gudnason, V, Folsom, AR, Andrews, G, Ballantyne, CM, Hall, AS, Braund, PS, Balmforth, AJ, Whincup, PH, Morris, R, Lawlor, DA, Lowe, GDO, Timpson, N, Ebrahim, S, Ben-Shlomo, Y, Tybjaerg-Hansen, A, Zacho, J, Brown, M, Ricketts, SL, Ashford, S, Lange, L, Reiner, A, Cushman, M, Tracy, R, Wu, C, Ge, J, Zou, Y, Sun, A, Hung, J , Mcquillan, B , Thompson, P, Beilby, J, Warrington, N, Palmer, LJ, Wanner, C, Drechsler, C, Hoffmann, MM, Fowkes, FGR, Tzoulaki, I, Kumari, M, Miller, M, Marmot, M, Onland-Moret, C, Van Der Schouw, YT, Boer, JM, Wijmenga, C, Ricketts, L, Khaw, KT, Vasan, RS, Schnabel, RB, Yamamoto, JF, Benjamin, EJ, Schunkert, H, Erdmann, J, Koenig, IR, Hengstenberg, C, Chiodini, B, Franzosi, MG, Pietri, S, Gori, F, Rudock, M, Liu, Y, Lohman, K, Humphries, SE, Hamsten, A, Norman, PE, Hankey, G, Jamrozik, K, Rimm, EB, Pai, JK, Psaty, BM, Heckbert, SR, Bis, JC, Yusuf, S, Xie, C, Collins, R, Bennett, D, Kooner, J, Chambers, J, Elliott, P, Maerz, W, Kleber, ME, Boehm, BO, Winkelmann, BR, Melander, O, Berglund, G, Koenig, W, Thorand, B, Baumert, J, Peters, A, Manson, J, Cooper, JA, Talmud, PJ, Ladenvall, P, Johansson, L, Jansson, JH, Hallmans, G, Reilly, MP, Qu, L, Li, M, Rader, DJ, Watkins, H, Hopewell, J, Frossard, P, Sattar, N, Robertson, M, Shepherd, J, Schaefer, E, Hofman, A, Witteman, JCM, Kardys, I, Dehghan, A, De Faire, U, Bennet, A, Gigante, B, Leander, K, Peters, B, Maitland-Van Der Zee, AH, De Boer, A, Klungel, O, Greenland, P, Dai, J, Liu, S, Brunner, E, Kivimaki, M, O'Reilly, D, Ford, I & Packard, CJ 2011, 'Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data', British Medical Journal, vol. 342, pp. 1-8. https://doi.org/10.1136/bmj.d548

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. / Wensley, F.; Gao, P.; Burgess, S.; Kaptoge, S.; Di Angelantonio, E.; Shah, T.; Engert, J.C.; Clarke, R.; Davey-Smith, G.; Nordestgaard, B.G.; Saleheen, D.; Samani, N.J.; Sandhu, M.; Anand, S.; Pepys, M.B.; Smeeth, L.; Whittaker, J.; Casas, J.P.; Thompson, S.G.; Hingorani, A.D.; Danesh, J.; Eiriksdottir, G.; Harris, T.B.; Launer, L.J.; Gudnason, V.; Folsom, A.R.; Andrews, G.; Ballantyne, C.M.; Hall, A.S.; Braund, P.S.; Balmforth, A.J.; Whincup, P.H.; Morris, R.; Lawlor, D.A.; Lowe, G.D.O.; Timpson, N.; Ebrahim, S.; Ben-Shlomo, Y.; Tybjaerg-Hansen, A.; Zacho, J.; Brown, M.; Ricketts, S.L.; Ashford, S.; Lange, L.; Reiner, A.; Cushman, M.; Tracy, R.; Wu, C.; Ge, J.; Zou, Y.; Sun, A.; Hung, Joe ; Mcquillan, Brendan ; Thompson, P.; Beilby, J.; Warrington, Nicole; Palmer, L.J.; Wanner, C.; Drechsler, C.; Hoffmann, M.M.; Fowkes, F.G.R.; Tzoulaki, I.; Kumari, M.; Miller, M.; Marmot, M.; Onland-Moret, C.; Van Der Schouw, Y.T.; Boer, J.M.; Wijmenga, C.; Ricketts, L.; Khaw, K.T.; Vasan, R.S.; Schnabel, R.B.; Yamamoto, J.F.; Benjamin, E.J.; Schunkert, H.; Erdmann, J.; Koenig, I.R.; Hengstenberg, C.; Chiodini, B.; Franzosi, M.G.; Pietri, S.; Gori, F.; Rudock, M.; Liu, Y.; Lohman, K.; Humphries, S.E.; Hamsten, A.; Norman, P.E.; Hankey, Graeme; Jamrozik, K.; Rimm, E.B.; Pai, J.K.; Psaty, B.M.; Heckbert, S.R.; Bis, J.C.; Yusuf, S.; Xie, C.; Collins, R.; Bennett, D.; Kooner, J.; Chambers, J.; Elliott, P.; Maerz, W.; Kleber, M.E.; Boehm, B.O.; Winkelmann, B.R.; Melander, O.; Berglund, G.; Koenig, W.; Thorand, B.; Baumert, J.; Peters, A.; Manson, J.; Cooper, J.A.; Talmud, P.J.; Ladenvall, P.; Johansson, L.; Jansson, J.H.; Hallmans, G.; Reilly, M.P.; Qu, L.; Li, M.; Rader, D.J.; Watkins, H.; Hopewell, J.; Frossard, P.; Sattar, N.; Robertson, M.; Shepherd, J.; Schaefer, E.; Hofman, A.; Witteman, J.C.M.; Kardys, I.; Dehghan, A.; De Faire, U.; Bennet, A.; Gigante, B.; Leander, K.; Peters, B.; Maitland-Van Der Zee, A.H.; De Boer, A.; Klungel, O.; Greenland, P.; Dai, J.; Liu, S.; Brunner, E.; Kivimaki, M.; O'Reilly, D.; Ford, I.; Packard, C.J.

In: British Medical Journal, Vol. 342, 2011, p. 1-8.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

AU - Wensley, F.

AU - Gao, P.

AU - Burgess, S.

AU - Kaptoge, S.

AU - Di Angelantonio, E.

AU - Shah, T.

AU - Engert, J.C.

AU - Clarke, R.

AU - Davey-Smith, G.

AU - Nordestgaard, B.G.

AU - Saleheen, D.

AU - Samani, N.J.

AU - Sandhu, M.

AU - Anand, S.

AU - Pepys, M.B.

AU - Smeeth, L.

AU - Whittaker, J.

AU - Casas, J.P.

AU - Thompson, S.G.

AU - Hingorani, A.D.

AU - Danesh, J.

AU - Eiriksdottir, G.

AU - Harris, T.B.

AU - Launer, L.J.

AU - Gudnason, V.

AU - Folsom, A.R.

AU - Andrews, G.

AU - Ballantyne, C.M.

AU - Hall, A.S.

AU - Braund, P.S.

AU - Balmforth, A.J.

AU - Whincup, P.H.

AU - Morris, R.

AU - Lawlor, D.A.

AU - Lowe, G.D.O.

AU - Timpson, N.

AU - Ebrahim, S.

AU - Ben-Shlomo, Y.

AU - Tybjaerg-Hansen, A.

AU - Zacho, J.

AU - Brown, M.

AU - Ricketts, S.L.

AU - Ashford, S.

AU - Lange, L.

AU - Reiner, A.

AU - Cushman, M.

AU - Tracy, R.

AU - Wu, C.

AU - Ge, J.

AU - Zou, Y.

AU - Sun, A.

AU - Hung, Joe

AU - Mcquillan, Brendan

AU - Thompson, P.

AU - Beilby, J.

AU - Warrington, Nicole

AU - Palmer, L.J.

AU - Wanner, C.

AU - Drechsler, C.

AU - Hoffmann, M.M.

AU - Fowkes, F.G.R.

AU - Tzoulaki, I.

AU - Kumari, M.

AU - Miller, M.

AU - Marmot, M.

AU - Onland-Moret, C.

AU - Van Der Schouw, Y.T.

AU - Boer, J.M.

AU - Wijmenga, C.

AU - Ricketts, L.

AU - Khaw, K.T.

AU - Vasan, R.S.

AU - Schnabel, R.B.

AU - Yamamoto, J.F.

AU - Benjamin, E.J.

AU - Schunkert, H.

AU - Erdmann, J.

AU - Koenig, I.R.

AU - Hengstenberg, C.

AU - Chiodini, B.

AU - Franzosi, M.G.

AU - Pietri, S.

AU - Gori, F.

AU - Rudock, M.

AU - Liu, Y.

AU - Lohman, K.

AU - Humphries, S.E.

AU - Hamsten, A.

AU - Norman, P.E.

AU - Hankey, Graeme

AU - Jamrozik, K.

AU - Rimm, E.B.

AU - Pai, J.K.

AU - Psaty, B.M.

AU - Heckbert, S.R.

AU - Bis, J.C.

AU - Yusuf, S.

AU - Xie, C.

AU - Collins, R.

AU - Bennett, D.

AU - Kooner, J.

AU - Chambers, J.

AU - Elliott, P.

AU - Maerz, W.

AU - Kleber, M.E.

AU - Boehm, B.O.

AU - Winkelmann, B.R.

AU - Melander, O.

AU - Berglund, G.

AU - Koenig, W.

AU - Thorand, B.

AU - Baumert, J.

AU - Peters, A.

AU - Manson, J.

AU - Cooper, J.A.

AU - Talmud, P.J.

AU - Ladenvall, P.

AU - Johansson, L.

AU - Jansson, J.H.

AU - Hallmans, G.

AU - Reilly, M.P.

AU - Qu, L.

AU - Li, M.

AU - Rader, D.J.

AU - Watkins, H.

AU - Hopewell, J.

AU - Frossard, P.

AU - Sattar, N.

AU - Robertson, M.

AU - Shepherd, J.

AU - Schaefer, E.

AU - Hofman, A.

AU - Witteman, J.C.M.

AU - Kardys, I.

AU - Dehghan, A.

AU - De Faire, U.

AU - Bennet, A.

AU - Gigante, B.

AU - Leander, K.

AU - Peters, B.

AU - Maitland-Van Der Zee, A.H.

AU - De Boer, A.

AU - Klungel, O.

AU - Greenland, P.

AU - Dai, J.

AU - Liu, S.

AU - Brunner, E.

AU - Kivimaki, M.

AU - O'Reilly, D.

AU - Ford, I.

AU - Packard, C.J.

PY - 2011

Y1 - 2011

N2 - Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein (P

AB - Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease.Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological studies in 15 countries.Participants 194 418 participants, including 46 557 patients with prevalent or incident coronary heart disease. Information was available on four CRP gene tagging single nucleotide polymorphisms (rs3093077, rs1205, rs1130864, rs1800947), concentration of C reactive protein, and levels of other risk factors.Main outcome measures Risk ratios for coronary heart disease associated with genetically raised C reactive protein versus risk ratios with equivalent differences in C reactive protein concentration itself, adjusted for conventional risk factors and variability in risk factor levels within individuals.Results CRP variants were each associated with up to 30% per allele difference in concentration of C reactive protein (P

U2 - 10.1136/bmj.d548

DO - 10.1136/bmj.d548

M3 - Article

VL - 342

SP - 1

EP - 8

JO - BMJ: British Medical Journal

JF - BMJ: British Medical Journal

SN - 0959-535X

ER -