Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population

M. Woodward; Kevin Croft; Trevor Mori; H.A. Headlam; X.S. Wang; C. Suarna; M. Raftery; S. Macmahon; R. Stockers

doi:10.1042/CS20070404

Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population

M. Woodward, Kevin Croft, Trevor Mori, H.A. Headlam, X.S. Wang, C. Suarna, M. Raftery, S. Macmahon, R. Stockers

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants have not generally been positive. In the present study, 227 coronary cases, identified from a cohort study, were matched, by age and gender, with 420 controls in a nested case-control design. Stored plasma samples were analysed for F2-isoprostanes by stable isotope dilution MS, and specifically oxidized forms of apoA-I (apolipoprotein A-I) by HPLC of HDL (high-density lipoprotein). Median values of F2-isoprostanes were higher in plasma samples that contained oxidized apoA-I compared with samples with undetectable oxidized apoA-I (1542 compared with 1165 pmol/l). F2-Isoprostanes were significantly correlated with variants of non-oxidized apoA-II (r=−0.15) and were associated with HDL-cholesterol (P

Original language	English
Pages (from-to)	53-60
Journal	Clinical Science
Volume	116
DOIs	https://doi.org/10.1042/CS20070404
Publication status	Published - 2009

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10.1042/CS20070404

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abstract = "The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants have not generally been positive. In the present study, 227 coronary cases, identified from a cohort study, were matched, by age and gender, with 420 controls in a nested case-control design. Stored plasma samples were analysed for F2-isoprostanes by stable isotope dilution MS, and specifically oxidized forms of apoA-I (apolipoprotein A-I) by HPLC of HDL (high-density lipoprotein). Median values of F2-isoprostanes were higher in plasma samples that contained oxidized apoA-I compared with samples with undetectable oxidized apoA-I (1542 compared with 1165 pmol/l). F2-Isoprostanes were significantly correlated with variants of non-oxidized apoA-II (r=−0.15) and were associated with HDL-cholesterol (P",

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T1 - Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population

AU - Woodward, M.

AU - Croft, Kevin

AU - Mori, Trevor

AU - Headlam, H.A.

AU - Wang, X.S.

AU - Suarna, C.

AU - Raftery, M.

AU - Macmahon, S.

AU - Stockers, R.

PY - 2009

Y1 - 2009

N2 - The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants have not generally been positive. In the present study, 227 coronary cases, identified from a cohort study, were matched, by age and gender, with 420 controls in a nested case-control design. Stored plasma samples were analysed for F2-isoprostanes by stable isotope dilution MS, and specifically oxidized forms of apoA-I (apolipoprotein A-I) by HPLC of HDL (high-density lipoprotein). Median values of F2-isoprostanes were higher in plasma samples that contained oxidized apoA-I compared with samples with undetectable oxidized apoA-I (1542 compared with 1165 pmol/l). F2-Isoprostanes were significantly correlated with variants of non-oxidized apoA-II (r=−0.15) and were associated with HDL-cholesterol (P

AB - The role of oxidative damage in the aetiology of coronary disease remains controversial, as clinical trials investigating the effect of antioxidants have not generally been positive. In the present study, 227 coronary cases, identified from a cohort study, were matched, by age and gender, with 420 controls in a nested case-control design. Stored plasma samples were analysed for F2-isoprostanes by stable isotope dilution MS, and specifically oxidized forms of apoA-I (apolipoprotein A-I) by HPLC of HDL (high-density lipoprotein). Median values of F2-isoprostanes were higher in plasma samples that contained oxidized apoA-I compared with samples with undetectable oxidized apoA-I (1542 compared with 1165 pmol/l). F2-Isoprostanes were significantly correlated with variants of non-oxidized apoA-II (r=−0.15) and were associated with HDL-cholesterol (P

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JO - Clinical Science

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ER -

Association between both lipid and protein oxidation and the risk of fatal or non-fatal coronary heart disease in a human population

Abstract

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