TY - JOUR
T1 - Association analysis of the HLA-C gene in Japanese alopecia areata
AU - Haida, Y.
AU - Ikeda, S.
AU - Takagi, A.
AU - Komiyama, E.
AU - Mabuchi, T.
AU - Ozawa, A.
AU - Kulski, Jerzy
AU - Inoko, H.
AU - Oka, A.
PY - 2013
Y1 - 2013
N2 - Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease involving hair loss, but its pathogenesis remains poorly understood. Many autoimmune diseases are genetically associated with alleles of the human leukocyte antigen (HLA) genes within the major histocompatibility complex. Associations between AA and HLA genes were previously observed in some different ethnic groups. However, the results were inconsistent, and a primary susceptibility HLA gene and/or region has not yet been assigned for AA. The aim of this study was to evaluate whether an allele of the HLA-C locus, HLA-C07:04, which was strongly associated with AA in Chinese Hans, could be replicated in the Japanese population. The HLA-C locus was genotyped by the SSO method using 156 AA patients and 560 healthy controls. As a consequence, among the 17 alleles detected, only two alleles, C04:01 (OR = 2.25, CI 95 % = 1.35-3.75, P = 1.84E-03) and C15:02 (OR = 2.52, CI 95 % = 1.37-4.64, P = 2.90E-03), were significantly associated with AA after Bonferroni correction. Further, the stratification analysis suggested that C04:01, C07:02, and C15:02 represented different AA genetic risk factors in each sub-phenotype. © 2013 Springer-Verlag Berlin Heidelberg.
AB - Alopecia areata (AA) is an organ-specific and cell-mediated autoimmune disease involving hair loss, but its pathogenesis remains poorly understood. Many autoimmune diseases are genetically associated with alleles of the human leukocyte antigen (HLA) genes within the major histocompatibility complex. Associations between AA and HLA genes were previously observed in some different ethnic groups. However, the results were inconsistent, and a primary susceptibility HLA gene and/or region has not yet been assigned for AA. The aim of this study was to evaluate whether an allele of the HLA-C locus, HLA-C07:04, which was strongly associated with AA in Chinese Hans, could be replicated in the Japanese population. The HLA-C locus was genotyped by the SSO method using 156 AA patients and 560 healthy controls. As a consequence, among the 17 alleles detected, only two alleles, C04:01 (OR = 2.25, CI 95 % = 1.35-3.75, P = 1.84E-03) and C15:02 (OR = 2.52, CI 95 % = 1.37-4.64, P = 2.90E-03), were significantly associated with AA after Bonferroni correction. Further, the stratification analysis suggested that C04:01, C07:02, and C15:02 represented different AA genetic risk factors in each sub-phenotype. © 2013 Springer-Verlag Berlin Heidelberg.
U2 - 10.1007/s00251-013-0703-z
DO - 10.1007/s00251-013-0703-z
M3 - Article
SN - 0093-7711
VL - 65
SP - 553
EP - 557
JO - Immunogenetics
JF - Immunogenetics
IS - 7
ER -
