Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P. Sklar, Sibylle Schwab, N.M. Williams, M. Daly, S. Schaffner, W. Maier, M. Albus, M. Trixler, P. Eichhammer, B. Lerer, J. Hallmayer, N. Norton, H. Williams, S. Zammit, A.G. Cardno, S. Jones, G. Mccarthy, V. Milanova, G. Kirov, M.C. O'DonovanE.S. Lander, M.J. Owen, Dieter Wildenauer

    Research output: Contribution to journalArticlepeer-review

    58 Citations (Scopus)

    Abstract

    A genetic association between NOTCH4 and schizophrenia has previously been proposed(1). Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton, These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
    Original languageEnglish
    Pages (from-to)126-128
    JournalNature Genetics
    Volume28
    DOIs
    Publication statusPublished - 2001

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