Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes

H. Kahles, Grant Morahan, J.A. Todd, K. Badenhoop

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27 Citations (Scopus)

Abstract

Type I diabetes (T1D) results from interactions between environmental exposures and genetic susceptibility leading to immune dysfunction and destruction of the insulin-producing β cells of the pancreas. Vitamin D deficiency is likely to be one of the many environmental factors influencing T1D development and diagnosis, and, hence, the hormone receptor gene, VDR, was examined for association with T1D risk. The Type I Diabetes Genetics Consortium genotyped 38 single nucleotide polymorphisms (SNPs) in 1654 T1D nuclear families (6707 individuals, 3399 affected). Genotypes for 38 SNPs were assigned using the Illumina (ILMN) and Sequenom (SQN) technology. The analysis of data release as of July 2008 is reported for both platforms. No evidence of association of VDR SNPs with T1D at P
Original languageEnglish
Pages (from-to)S60-S63
Number of pages4
JournalGenes & Immunity
Volume10
Issue numbersupp. 1
DOIs
Publication statusPublished - Dec 2009

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