Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

Ewa Maczynska, Karol Karnowski, Krzysztof Szulzycki, Monika Malinowska, Hubert Dolezyczek, Artur Cichanski, Maciej Wojtkowski, Bartlomiej Kaluzny, Ireneusz Grulkowski

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

Original languageEnglish
Article number201800154
Number of pages9
JournalJournal of Biophotonics
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2019

Cite this

Maczynska, Ewa ; Karnowski, Karol ; Szulzycki, Krzysztof ; Malinowska, Monika ; Dolezyczek, Hubert ; Cichanski, Artur ; Wojtkowski, Maciej ; Kaluzny, Bartlomiej ; Grulkowski, Ireneusz. / Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis. In: Journal of Biophotonics. 2019 ; Vol. 12, No. 2.
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abstract = "Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.",
keywords = "corneal biomechanics, corneal hysteresis, optical coherence tomography, viscoelasticity, COLLAGEN CROSS-LINKING, BIOMECHANICAL PROPERTIES, ELASTOGRAPHY, ELASTICITY, OCT, DEFORMATION, RIBOFLAVIN/ULTRAVIOLET, ARCHITECTURE, MICROSCOPY, STRAIN",
author = "Ewa Maczynska and Karol Karnowski and Krzysztof Szulzycki and Monika Malinowska and Hubert Dolezyczek and Artur Cichanski and Maciej Wojtkowski and Bartlomiej Kaluzny and Ireneusz Grulkowski",
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Maczynska, E, Karnowski, K, Szulzycki, K, Malinowska, M, Dolezyczek, H, Cichanski, A, Wojtkowski, M, Kaluzny, B & Grulkowski, I 2019, 'Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis' Journal of Biophotonics, vol. 12, no. 2, 201800154. https://doi.org/10.1002/jbio.201800154

Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis. / Maczynska, Ewa; Karnowski, Karol; Szulzycki, Krzysztof; Malinowska, Monika; Dolezyczek, Hubert; Cichanski, Artur; Wojtkowski, Maciej; Kaluzny, Bartlomiej; Grulkowski, Ireneusz.

In: Journal of Biophotonics, Vol. 12, No. 2, 201800154, 02.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air-puff optical coherence tomography and corneal hysteresis

AU - Maczynska, Ewa

AU - Karnowski, Karol

AU - Szulzycki, Krzysztof

AU - Malinowska, Monika

AU - Dolezyczek, Hubert

AU - Cichanski, Artur

AU - Wojtkowski, Maciej

AU - Kaluzny, Bartlomiej

AU - Grulkowski, Ireneusz

PY - 2019/2

Y1 - 2019/2

N2 - Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

AB - Application of the air-puff swept source optical coherence tomography (SS-OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air-puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time-evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well-controlled intraocular pressure (IOP) levels and for the progression of cross-linking-induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air-puff SS-OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.

KW - corneal biomechanics

KW - corneal hysteresis

KW - optical coherence tomography

KW - viscoelasticity

KW - COLLAGEN CROSS-LINKING

KW - BIOMECHANICAL PROPERTIES

KW - ELASTOGRAPHY

KW - ELASTICITY

KW - OCT

KW - DEFORMATION

KW - RIBOFLAVIN/ULTRAVIOLET

KW - ARCHITECTURE

KW - MICROSCOPY

KW - STRAIN

U2 - 10.1002/jbio.201800154

DO - 10.1002/jbio.201800154

M3 - Article

VL - 12

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-0648

IS - 2

M1 - 201800154

ER -