Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

K.T. Batty, Kenneth Ilett, G. Edwards, S.M. Powell, J.L. Maggs, B.K. Park, T.M.E. Davis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

1 The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies.2 In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 mi min(-1) in controls (n=8) to 6.0+/-1.0 mi min(-1) in MI (n=8; P
Original languageEnglish
Pages (from-to)159-167
JournalBritish Journal of Pharmacology
Volume124
DOIs
Publication statusPublished - 1998

Fingerprint

Dive into the research topics of 'Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes'. Together they form a unique fingerprint.

Cite this