Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

K.T. Batty; Kenneth Ilett; G. Edwards; S.M. Powell; J.L. Maggs; B.K. Park; T.M.E. Davis

doi:10.1038/sj.bjp.0702023

Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

K.T. Batty, Kenneth Ilett, G. Edwards, S.M. Powell, J.L. Maggs, B.K. Park, T.M.E. Davis

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Abstract

1 The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies.2 In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 mi min(-1) in controls (n=8) to 6.0+/-1.0 mi min(-1) in MI (n=8; P

Original language	English
Pages (from-to)	159-167
Journal	British Journal of Pharmacology
Volume	124
DOIs	https://doi.org/10.1038/sj.bjp.0702023
Publication status	Published - 1998

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title = "Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes",

abstract = "1 The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies.2 In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 mi min(-1) in controls (n=8) to 6.0+/-1.0 mi min(-1) in MI (n=8; P",

author = "K.T. Batty and Kenneth Ilett and G. Edwards and S.M. Powell and J.L. Maggs and B.K. Park and T.M.E. Davis",

year = "1998",

doi = "10.1038/sj.bjp.0702023",

language = "English",

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pages = "159--167",

journal = "British Journal of Pharmacology",

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T1 - Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

AU - Batty, K.T.

AU - Ilett, Kenneth

AU - Edwards, G.

AU - Powell, S.M.

AU - Maggs, J.L.

AU - Park, B.K.

AU - Davis, T.M.E.

PY - 1998

Y1 - 1998

N2 - 1 The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies.2 In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 mi min(-1) in controls (n=8) to 6.0+/-1.0 mi min(-1) in MI (n=8; P

AB - 1 The clearance of dihydroartemisinin (DHA) in control and malaria-infected (MI) rats was investigated using the isolated perfused rat liver (IPRL) model and hepatic microsomal studies.2 In the recirculating IPRL, clearance of DHA was reduced from a mean (s.d.) of 8.2+/-1.8 mi min(-1) in controls (n=8) to 6.0+/-1.0 mi min(-1) in MI (n=8; P

U2 - 10.1038/sj.bjp.0702023

DO - 10.1038/sj.bjp.0702023

M3 - Article

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VL - 124

SP - 159

EP - 167

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

ER -

Assessment of the effect of malaria infection on hepatic clearance of dihydroartemisinin using rat liver perfusions and microsomes

Abstract

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