The non-motor symptoms (NMS) of Parkinson's disease (PD) are debilitating for patients, yet little is known about their onset and severity. This thesis comprehensively evaluated multiple PD cohorts, finding that patient biological sex was predictive of longitudinal cognitive decline. Secondly, blood levels of cholesterol, homocysteine and ceruloplasmin were associated with cognitive ability and related psychiatric NMS, impulsivity. Finally, the TOMM40'523' genetic variant, previously linked to Alzheimer's, was associated with age of PD symptom onset and progression to dementia, in sex-specific fashion. These findings help explain variability of NMS in PD, and may allow for the development of more informative PD biomarkers.
|Qualification||Doctor of Philosophy|
|Award date||24 Sept 2021|
|Publication status||Unpublished - 2021|