Assessment of the determinants of cognitive decline and related symptoms in Parkinson’s disease

Megan Bakeberg

doi:10.26182/1n3g-ed84

Assessment of the determinants of cognitive decline and related symptoms in Parkinson’s disease

Megan Bakeberg

Research output: Thesis › Doctoral Thesis

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Abstract

The non-motor symptoms (NMS) of Parkinson's disease (PD) are debilitating for patients, yet little is known about their onset and severity. This thesis comprehensively evaluated multiple PD cohorts, finding that patient biological sex was predictive of longitudinal cognitive decline. Secondly, blood levels of cholesterol, homocysteine and ceruloplasmin were associated with cognitive ability and related psychiatric NMS, impulsivity. Finally, the TOMM40'523' genetic variant, previously linked to Alzheimer's, was associated with age of PD symptom onset and progression to dementia, in sex-specific fashion. These findings help explain variability of NMS in PD, and may allow for the development of more informative PD biomarkers.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Anderton, Ryan, Supervisor Byrnes, Michelle, Supervisor Palmer, Norman, Supervisor Mastaglia, Frank, Supervisor Stell, Rick, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	24 Sept 2021
DOIs	https://doi.org/10.26182/1n3g-ed84
Publication status	Unpublished - 2021

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10.26182/1n3g-ed84

THESIS - DOCTOR OF PHILOSOPHY - BAKEBERG Megan Carol - 2021
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Cite this

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abstract = "The non-motor symptoms (NMS) of Parkinson's disease (PD) are debilitating for patients, yet little is known about their onset and severity. This thesis comprehensively evaluated multiple PD cohorts, finding that patient biological sex was predictive of longitudinal cognitive decline. Secondly, blood levels of cholesterol, homocysteine and ceruloplasmin were associated with cognitive ability and related psychiatric NMS, impulsivity. Finally, the TOMM40'523' genetic variant, previously linked to Alzheimer's, was associated with age of PD symptom onset and progression to dementia, in sex-specific fashion. These findings help explain variability of NMS in PD, and may allow for the development of more informative PD biomarkers.",

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AB - The non-motor symptoms (NMS) of Parkinson's disease (PD) are debilitating for patients, yet little is known about their onset and severity. This thesis comprehensively evaluated multiple PD cohorts, finding that patient biological sex was predictive of longitudinal cognitive decline. Secondly, blood levels of cholesterol, homocysteine and ceruloplasmin were associated with cognitive ability and related psychiatric NMS, impulsivity. Finally, the TOMM40'523' genetic variant, previously linked to Alzheimer's, was associated with age of PD symptom onset and progression to dementia, in sex-specific fashion. These findings help explain variability of NMS in PD, and may allow for the development of more informative PD biomarkers.

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KW - cognitive decline

KW - non-motor symptoms

KW - genetic biomarkers

KW - serum biomarkers

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DO - 10.26182/1n3g-ed84

M3 - Doctoral Thesis

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Assessment of the determinants of cognitive decline and related symptoms in Parkinson’s disease

Abstract

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