Assessment of the determinants of cognitive decline and related symptoms in Parkinson’s disease

Research output: ThesisDoctoral Thesis

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Abstract

The non-motor symptoms (NMS) of Parkinson's disease (PD) are debilitating for patients, yet little is known about their onset and severity. This thesis comprehensively evaluated multiple PD cohorts, finding that patient biological sex was predictive of longitudinal cognitive decline. Secondly, blood levels of cholesterol, homocysteine and ceruloplasmin were associated with cognitive ability and related psychiatric NMS, impulsivity. Finally, the TOMM40'523' genetic variant, previously linked to Alzheimer's, was associated with age of PD symptom onset and progression to dementia, in sex-specific fashion. These findings help explain variability of NMS in PD, and may allow for the development of more informative PD biomarkers.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Anderton, Ryan, Supervisor
  • Byrnes, Michelle, Supervisor
  • Palmer, Norman, Supervisor
  • Mastaglia, Frank, Supervisor
  • Stell, Rick, Supervisor
Thesis sponsors
Award date24 Sept 2021
DOIs
Publication statusUnpublished - 2021

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