Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

G. Cuellar-Partida, J.E. Craig, K.P. Burdon, J.J. Wang, B.J. Vote, E. Souzeau, Ian L. Mcallister, Timothy Isaacs, S. Lake, David A. Mackey, Ian J. Constable, P. Mitchell, A.W. Hewitt, S. Macgregor

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13 Citations (Scopus)

Abstract

Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated the genetic architecture of POAG and AMD using genome-wide array data. We estimated the heritability for POAG (h2g = 0.42 ± 0.09) and AMD (h2g = 0.71 ± 0.08). Removing known loci for POAG and AMD decreased the h2g estimates to 0.36 and 0.24, respectively. There was evidence for a positive genetic correlation between POAG and AMD (rg = 0.47 ± 0.25) which remained after removing known loci (rg = 0.64 ± 0.31). We also found that the genetic correlation between sexes for POAG was likely to be less than 1 (rg = 0.33 ± 0.24), suggesting that differences of prevalence among genders may be partly due to heritable factors.
Original languageEnglish
Article number26885
Pages (from-to)1-6
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 31 May 2016

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