Assessing the relationship between maternal cocaine use and abruptio placentae

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Abstract

Abruptio placentae during pregnancy can result in significant morbidity and mortality to both mother and infant A comprehensive literature search of publications from 1966 to April 1995 identified fl studies on the association between maternal cocaine use and abruptio placentae. Their results were combined in a meta-analysis. The pooled odds ratio for abruptio placentae and maternal cocaine use was 3.92 (95% confidence interval 2.77-5.46). The strength and consistency of the association, its biological plausibility and the results of experimental studies in animals all suggest that cocaine use during pregnancy causes abruptio placentae.
Original languageEnglish
Pages (from-to)1547-1551
JournalAddiction
Volume92
Issue number11
DOIs
Publication statusPublished - 1997

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