Aspects of Clostridium difficile infection in pigs

Peter Moono

Research output: ThesisDoctoral Thesis

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Abstract

Clostridium difficile infection (CDi) is a well-known cause of diarrhoea in immuno-compromised humans. CDI is also a recognised cause of enteritis in piglets which can result in stuntedness/delayed weaning. C. difficile is an anaerobic bacterium, which produces toxin A, B, and/binary toxin as virulence factors. In this thesis, it was found that identifying farms without C. difficile through screening Is an important step in preventing human exposure. Although zoonotic transmission has not been reported, evidence suggests that it Is occurring. This work suggests that lawns farmed with contaminated manure could be a reservoir for COi. Passive immunotransfer could reduce spore shedding.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date15 Nov 2017
DOIs
Publication statusUnpublished - 2017

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Clostridium Infections
Clostridium difficile
Swine
Manure
Enteritis
Anaerobic Bacteria
Zoonoses
Virulence Factors
Weaning
Spores
Diarrhea

Cite this

@phdthesis{402319726e734725890ab11f8168e385,
title = "Aspects of Clostridium difficile infection in pigs",
abstract = "Clostridium difficile infection (CDi) is a well-known cause of diarrhoea in immuno-compromised humans. CDI is also a recognised cause of enteritis in piglets which can result in stuntedness/delayed weaning. C. difficile is an anaerobic bacterium, which produces toxin A, B, and/binary toxin as virulence factors. In this thesis, it was found that identifying farms without C. difficile through screening Is an important step in preventing human exposure. Although zoonotic transmission has not been reported, evidence suggests that it Is occurring. This work suggests that lawns farmed with contaminated manure could be a reservoir for COi. Passive immunotransfer could reduce spore shedding.",
keywords = "Clostridium difficile infection, Neonatal pig CDI, C. difficile epidemiology, Environmetal contamination, Immunotherapy for CDI, Toxoid vaccine",
author = "Peter Moono",
year = "2017",
doi = "10.4225/23/5a14e6cddc5de",
language = "English",
school = "The University of Western Australia",

}

Moono, P 2017, 'Aspects of Clostridium difficile infection in pigs', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.4225/23/5a14e6cddc5de

Aspects of Clostridium difficile infection in pigs. / Moono, Peter.

2017.

Research output: ThesisDoctoral Thesis

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T1 - Aspects of Clostridium difficile infection in pigs

AU - Moono, Peter

PY - 2017

Y1 - 2017

N2 - Clostridium difficile infection (CDi) is a well-known cause of diarrhoea in immuno-compromised humans. CDI is also a recognised cause of enteritis in piglets which can result in stuntedness/delayed weaning. C. difficile is an anaerobic bacterium, which produces toxin A, B, and/binary toxin as virulence factors. In this thesis, it was found that identifying farms without C. difficile through screening Is an important step in preventing human exposure. Although zoonotic transmission has not been reported, evidence suggests that it Is occurring. This work suggests that lawns farmed with contaminated manure could be a reservoir for COi. Passive immunotransfer could reduce spore shedding.

AB - Clostridium difficile infection (CDi) is a well-known cause of diarrhoea in immuno-compromised humans. CDI is also a recognised cause of enteritis in piglets which can result in stuntedness/delayed weaning. C. difficile is an anaerobic bacterium, which produces toxin A, B, and/binary toxin as virulence factors. In this thesis, it was found that identifying farms without C. difficile through screening Is an important step in preventing human exposure. Although zoonotic transmission has not been reported, evidence suggests that it Is occurring. This work suggests that lawns farmed with contaminated manure could be a reservoir for COi. Passive immunotransfer could reduce spore shedding.

KW - Clostridium difficile infection

KW - Neonatal pig CDI

KW - C. difficile epidemiology

KW - Environmetal contamination

KW - Immunotherapy for CDI

KW - Toxoid vaccine

U2 - 10.4225/23/5a14e6cddc5de

DO - 10.4225/23/5a14e6cddc5de

M3 - Doctoral Thesis

ER -