Aspects of cardiovascular risk stratification and management of familial hypercholesterolaemia

Research output: ThesisDoctoral Thesis

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Abstract

Familial hypercholesterolaemia (FH) causes cardiovascular disease from a young age, due to extremely high plasma concentrations of LDL-cholesterol. This thesis examines (1) the use of genetic risk predictors of cardiovascular disease in patients with FH, and (2) the use of advanced therapies (liver transplantation and lipoprotein apheresis) in patients with the most severe forms of FH. Some genetic markers predicted risk, but their clinical utility remains uncertain. Advanced therapies for severe FH were generally well-tolerated and feasible, with excellent long-term outcomes. Advances in risk prediction and therapy have the potential to improve the care of FH.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Watts, Gerald, Supervisor
  • Bell, Damon, Supervisor
  • Chan, Dick, Supervisor
  • Pang, Jing, Supervisor
Thesis sponsors
Award date30 Jul 2024
DOIs
Publication statusUnpublished - 2024

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