Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways

Lilei He, Guoju Hong, Lin Zhou, Jianguo Zhang, Jian Fang, Wei He, Jennifer Tickner, Xiaorui Han, Lilian Zhao, Jiake Xu

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Identification of natural compounds that inhibit osteoclastogenesis will facilitate the development of antiresorptive treatment of osteolytic bone diseases. Asiaticoside is a triterpenoid derivative isolated from Centella asiatica, which exhibits varying biological effects like angiogenesis, anti-inflammation, wound healing, and osteogenic differentiation. However, its role in osteoclastogenesis remains unknown. Here, we show that Asiaticoside can suppress RANKL-induced osteoclast formation and bone resorption in a dose-dependent manner. Asiaticoside attenuated the expression of osteoclast marker genes including Ctsk, Atp6v0d2, Nfatc1, Acp5, and Dc-stamp. Furthermore, Asiaticoside inhibited RANKL-mediated NF-B and NFATc1 activities, and RANKL-induced calcium oscillation. Collectively, this study demonstrates that Asiaticoside inhibited osteoclast formation and function through attenuating RANKL-induced key signaling pathways, which may indicate that Asiaticoside is a potential antiresorptive agent against osteoclast-related osteolytic bone diseases.

Original languageEnglish
Pages (from-to)4267-4276
Number of pages10
JournalJournal of Cellular Physiology
Volume234
Issue number4
DOIs
Publication statusPublished - Apr 2019

Fingerprint

Dive into the research topics of 'Asiaticoside, a component of Centella asiatica attenuates RANKL-induced osteoclastogenesis via NFATc1 and NF-kappa B signaling pathways'. Together they form a unique fingerprint.

Cite this