TY - JOUR
T1 - Asbestosis and Idiopathic Pulmonary Fibrosis: Comparison of Thin-Section CT Features
AU - Copley, S.J.
AU - Wells, A.U.
AU - Sivakumaran, P.
AU - Rubens, M.B.
AU - Lee, Gary
AU - Desai, S.R.D.
AU - Macdonald, S.L.
AU - Thompson, R.
AU - Nicholson, A.G.
AU - Du Bois, R.M.
AU - Musk, Arthur
AU - Hansell, D.M.
PY - 2003
Y1 - 2003
N2 - PURPOSE: To identify differences, if any, in thin-section computed tomographic (CT) features between asbestosis and idiopathic pulmonary fibrosis (IPF) and to test the findings in a subset of histopathologically proved cases of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP).MATERIALS AND METHODS: Consecutive patients with a diagnosis of IPF (n 212) or asbestosis (n = 74) were included. The relationships derived from the initial comparison were tested in a separate group of biopsy-proved UIP (n = 30) and NSIP (n = 23) cases. Two observers independently scored thin-section CT images for extent, distribution, and coarseness of fibrosis; proportion of ground-glass opacification; severity of traction bronchiectasis; and extent of emphysema.RESULTS: After controlling for extent of fibrosis, patients with asbestosis had coarser fibrosis than those with IPF (odds ratio, 1.52; 95% CI: 1.25, 1.84; P < .001). Compared with the biopsy-proved cases, the asbestosis cases involved coarser fibrosis (after controlling for disease extent) than the NSIP cases (odds ratio, 2.48; 95% CI: 1.49, 4.11; P < .001) but fibrosis similar to that in the UIP cases. A basal and subpleural distribution of disease was usual in all subgroups but significantly more prevalent (P < .01 to .001) with asbestosis than with UIP or NSIP.CONCLUSION: The thin-section CT pattern of asbestosis closely resembles that of biopsy-proved UIP and differs markedly from that of biopsy-proved NSIP. RSNA 2003.
AB - PURPOSE: To identify differences, if any, in thin-section computed tomographic (CT) features between asbestosis and idiopathic pulmonary fibrosis (IPF) and to test the findings in a subset of histopathologically proved cases of usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP).MATERIALS AND METHODS: Consecutive patients with a diagnosis of IPF (n 212) or asbestosis (n = 74) were included. The relationships derived from the initial comparison were tested in a separate group of biopsy-proved UIP (n = 30) and NSIP (n = 23) cases. Two observers independently scored thin-section CT images for extent, distribution, and coarseness of fibrosis; proportion of ground-glass opacification; severity of traction bronchiectasis; and extent of emphysema.RESULTS: After controlling for extent of fibrosis, patients with asbestosis had coarser fibrosis than those with IPF (odds ratio, 1.52; 95% CI: 1.25, 1.84; P < .001). Compared with the biopsy-proved cases, the asbestosis cases involved coarser fibrosis (after controlling for disease extent) than the NSIP cases (odds ratio, 2.48; 95% CI: 1.49, 4.11; P < .001) but fibrosis similar to that in the UIP cases. A basal and subpleural distribution of disease was usual in all subgroups but significantly more prevalent (P < .01 to .001) with asbestosis than with UIP or NSIP.CONCLUSION: The thin-section CT pattern of asbestosis closely resembles that of biopsy-proved UIP and differs markedly from that of biopsy-proved NSIP. RSNA 2003.
U2 - 10.1148/radiol.2293020668
DO - 10.1148/radiol.2293020668
M3 - Article
C2 - 14576443
VL - 229
SP - 731
EP - 736
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -