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Abstract
Artemisinin derivatives are widely used antimalarial drugs. There is some evidence from in vitro, animal and clinical studies that hemoglobinopathies may alter their disposition and antimalarial activity. This review assesses relevant data in α-thalassemia, sickle cell disease (SCD), β-thalassemia and hemoglobin E. There is no convincing evidence that the disposition of artemisinin drugs is affected by hemoglobinopathies. Although in vitro studies indicate that Plasmodium falciparum cultured in thalassemic erythrocytes is relatively resistant to the artemisinin derivatives, mean 50% inhibitory concentrations (IC50s) are much lower than in vivo plasma concentrations after recommended treatment doses. Since IC50s are not increased in P. falciparum cultures using SCD erythrocytes, delayed post-treatment parasite clearance in SCD may reflect hyposplenism. As there have been no clinical studies suggesting that hemoglobinopathies significantly attenuate the efficacy of artemisinin combination therapy (ACT) in uncomplicated malaria, recommended artemisinin doses as part of ACT remain appropriate in this patient group.
Original language | English |
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Pages (from-to) | 799-804 |
Number of pages | 6 |
Journal | Clinical Infectious Diseases |
Volume | 66 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Mar 2018 |
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Dive into the research topics of 'Artemisinin therapy for malaria in hemoglobinopathies: A systematic review'. Together they form a unique fingerprint.Projects
- 1 Finished
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Timothy Davis
Davis, T. (Investigator 01)
NHMRC National Health and Medical Research Council
1/01/14 → 31/12/18
Project: Research
Research output
- 7 Citations
- 1 Doctoral Thesis
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A study of pharmacokinetic properties of artemisinin combination therapy for malaria in specific populations
Sugiarto, S. R., 2023, (Unpublished)Research output: Thesis › Doctoral Thesis
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