Aquisição passiva de anticorpos anti- Dermatophagoides pteronyssinus através de passagem transplacentária e aleitamento materno*

Translated title of the contribution: Passive acquisition of anti-Dermatophagoides pteronyssinus antibodies through placental transfer and breastfeeding

Patricia Macchiaverni, Josias Fraz~ao, Christina Arslanian, Patricia Palmeira, Silvana Severino, Antonio Condino-Neto

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction and objectives: The early life sensitization might be one of the primary causes of the increased prevalence of allergy. Considering that infants received in the uteri and by the breastfeed specific antibodies to allergens, we investigated the passive transference of IgG and IgA antibodies to Dermatophagoides pteronyssinus to verify if mother sensitization influences the humoral immune response in umbilical cord blood and in colostrum. Methods: Colostra and paired samples of maternal and umbilical cord blood were collected from 13 sensitized (IgE anti- -Der p > class 3) and 25 non-sensitized mothers. The samples were quantified for total and anti-Der p IgA and IgG levels by ELISA and analyzed to avidity. Results: Newborns of sensitized mothers presented significant higher levels of IgG anti-Der p (p=0,01), however, it was detected in all samples and IgG anti-Der p antibody levels in cord blood showed a strong correlation with the maternal levels (r=0.81 p<0.001). There was no statistical difference in S- -IgA levels between sensitized and non-sensitized mothers. Maternal and cord blood avidity was strongly correlated in both groups (r=0,92, p<0.0001). Conclusion: It is clear that infants receive IgG and IgA antibodies to Der p from mothers who didn’t have IgE antibodies to this mite. However, the fact that the placental transfer of total and specific IgG is correlated to maternal specific and total IgE levels, indicates that maternal sensitization influences the fetal immune response.
Translated title of the contributionPassive acquisition of anti-Dermatophagoides pteronyssinus antibodies through placental transfer and breastfeeding
Original languagePortuguese
Article number08/31-01/23
Pages (from-to)23-30
JournalArquivos de Asma, Alergia e Imunologia
Publication statusPublished - 2008
Externally publishedYes

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