Purpose of Review: This article summarizes the currently available published literature with regard to the applications of artificial intelligence in cardiac computed tomography angiography. Recent Findings: Recent studies and emerging data demonstrate feasibility of artificial intelligence-based high-level image analysis and interpretation tools that will likely enable medical practitioners to achieve more accurate diagnosis of coronary artery disease. Emerging artificial intelligence-based computational modeling methods will assist with pre-operative planning for valve disease. Finally, early but significant work is also being performed in relation to real-time assessment of myocardial perfusion and fractional flow reserve using machine learning. Summary: We anticipate that within the next 5 years, the level of artificial intelligence-driven automation for the analysis and interpretation of cardiac computed tomography angiography will be significantly higher than what is available today. It is also expected that the most productive applications of artificial intelligence in cardiac computed tomography angiography will involve deep learning, utilizing a combination of imaging data and adjunctive data mining to generate more accurate and personalized diagnoses and risk metrics.