Appetite Regulation and the Peripheral Sink Amyloid beta Clearance Pathway in Diabetes and Alzheimer’s Disease

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Abstract

The peripheral sink amyloid beta clearance pathway in diabetes and Alzheimer’s disease is defective. Appetite control and intact Sirtuin 1 are critical to prevent inactivation of the peripheral sink amyloid beta clearance pathway. Factors such as drugs, caffeine, Indian spices, LPS, mycotoxins and environmental xenobiotics determine longevity in various species when compared to man. Sirt 1 and circadian regula¬tion of the adipose tissue-liver interaction are essential to determine toxic antigenic Aβ structures with immune dysregulation connected to diabetes and Alzheimer’s disease.
Original languageEnglish
Title of host publicationTop 10 commentaries in Alzheimer's Disease
Place of PublicationUSA
PublisherAvid Science
Chapter1
Pages2-11
Number of pages11
Volume1
Edition1
Publication statusPublished - 2019

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