The apelinergic system and its relevance to endocrinology and diabetes has become of major importance to the global chronic disease epidemic. Apelinergic dysregulation is associated with appetite dysregulation and connected to insulin resistance and various organ diseases that include the heart, adipose tissue, liver and the brain. The peptide apelin and its receptor APJ (G protein-coupled receptor) play an important role in various tissues and the role in stress, insulin resistance, hormone release, thermoregulation, food intake and water balance are critical to endocrinology and diabetes. Recent studies have indicated that apelin is now identified as an anti-aging factor and its inactivation leads to a decline in the apelinergic axis with accelerated aging and programmed cell death that is linked to endocrinology, diabetes and neurodegenerative disease with relevance to the global chronic disease epidemic . Apelin regulates the aging process by interactions with sirtuins and its regulation of sirtuins 1-7 is critical in the prevention of the accelerated aging process and chronic disease.