Appetite control is involved in immunotherapy with relevance to cardiovascular disease, NAFLD and diabetes

Appetite control with relevance to immunometabolism has become critical to the treatment of non alcoholic fatty liver disease (NAFLD) and diabetes (1,2). Anti-aging genes (3,4) and their connections to autoimmune disease and mitophagy now identify the anti-aging gene Sirtuin 1 (Sirt 1) to be defective with increased heat shock proteins (HSP) involved in autoimmune disease and mitophagy (5) connected to irreversible programmed cell death in global populations. Appetite control or food restriction is required to maintain the heat shock gene Sirt 1 (6,7) that regulates HSP, amyloid beta and nitric oxide metabolism that are connected to natural killer cell activity, mitophagy and autoimmune disease in diabetes. Nutritional regulation of Sirt 1 with relevance to antimicrobial activity in humans (8) has become important to immunotherapy and the clinical treatment of NAFLD and diabetes. Nutritional diets that contain Sirt 1 activators have become vital to immunotherapy research to maintain immunometabolism and prevent mitophagy. Science and medicine and its relevance to genomic medicine (9) needs to consider Sirt 1 gene expression with its relevance to accelerated immune reactions that trigger acute cardiovascular disease. Various factors need to be considered as the trigger for toxic immune reactions with relevance to the progression of cardiovascular disease, NAFLD and diabetes. REFERENCES: 1. Martins IJ. Appetite Control and Nutrigenomic Diets are Connected to Immune Regulation and Diabetes Prevention. EC Nutrition 12.3 (2017): 120-123. 2. Martins IJ. Appetite Control with Relevance to Mitochondrial Biogenesis and Activation of Post- Prandial Lipid Metabolism in Obesity Linked Diabetes. Ann Obes Disord. 2016; 1(3): 1012. 3. Martins IJ. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26. 4. Martins IJ. Autoimmune disease and mitochondrial dysfunction in chronic diseases. Res Chron Dis (2017) 1(1). 5. Martins IJ. Defective Inter¬play between Adipose Tissue and Immune System Induces Non Alcoholic Fatty Liver Disease. Updates Nutr Disorders Ther. 2017; 1: 3.1. 6. Martins IJ. Heat shock gene Sirtuin 1 regulates post-prandial lipid metabolism with relevance to nutrition and appetite regulation in diabetes. International Journal of Diabetes and Clinical Diagnosis. Int J Diab Clin Diagn. 2016, 3:20. 7. Martins IJ. Type 3 diabetes with links to NAFLD and Other Chronic Diseases in the Western World. International Journal of Diabetes. 2016; 1:1-5. 8. Martins IJ. Antimicrobial activity inactivation and toxic immune reactions induce Epilepsy in human. J Med Discov (2017);2(4):jmd17040. 9. Martins IJ. Genomic medicine and acute cardiovascular disease progression in diabetes. Res Chron Dis (2018) 2(1), 001–003