TY - JOUR
T1 - Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal
AU - Needham, M.
AU - Hooper, A.
AU - James, I.
AU - Van Bockxmeer, Frank
AU - Corbett, A.
AU - Day, T.
AU - Garlepp, M.J.
AU - Mastaglia, Francis
PY - 2008
Y1 - 2008
N2 - Previous studies have differed as to whether APOE 84 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOE alleles on disease expression. Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon 2 allele. Crown copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
AB - Previous studies have differed as to whether APOE 84 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOE alleles on disease expression. Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon 2 allele. Crown copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
U2 - 10.1016/j.nmd.2007.09.005
DO - 10.1016/j.nmd.2007.09.005
M3 - Review article
C2 - 18060780
SN - 0960-8966
VL - 18
SP - 150
EP - 152
JO - Neuromuscular Disorders
JF - Neuromuscular Disorders
IS - 2
ER -