Apolipoprotein epsilon alleles in sporadic inclusion body myositis: a reappraisal

M. Needham, A. Hooper, I. James, Frank Van Bockxmeer, A. Corbett, T. Day, M.J. Garlepp, Francis Mastaglia

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Previous studies have differed as to whether APOE 84 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOE alleles on disease expression. Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon 2 allele. Crown copyright (C) 2007 Published by Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)150-152
JournalNeuromuscular Disorders
Volume18
Issue number2
DOIs
Publication statusPublished - 2008

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