Apolipoprotein E4 is Associated with Reduced Calcaneal Quantitative Ultrasound Measurements and Bone Mineral Density in Elderly Women

Ian Dick, A. Devine, Andrew Marangou, S.S. Dhaliwal, S. Laws, R.N. Martins, Richard Prince

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Some studies have reported an association between the apolipoprotein E4 (APOE4) allele and reduced bone density and increased propensity to fracture, but this remains controversial as other studies have not found an association between APOE4 and bone density or fracture. No information is available concerning the effect of the APOE4 allele on quantitative ultrasound (QUS) parameters. We therefore examined this issue in a population-based study of 1332 healthy elderly women, examining the effect of the APOE4 allele on QUS parameters at the calcaneus and comparing this to dual-energy X-ray absorptiometry (DEXA) bone mineral density (BNID) at the hip. In addition, we examined the effect of the APOE4 allele on fracture. Subjects who had at least one APOE4 allele (n = 308) had lower calcaneal QUS parameters and lower hip BNID at the total hip, trochanter, and intertrochanter, but not the femoral neck, compared to subjects without an APOE4 allele (n = 1024) after adjustment for age, body mass index (BMI), and smoking. The decrement in QUS parameters and BNID was approximately 2%. Those subjects having an APOE4 allele were also more likely to fall into a low bone density group, defined by a T score of
Original languageEnglish
Pages (from-to)497-502
JournalBone
Volume31
Issue number4
DOIs
Publication statusPublished - 2002

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Apolipoprotein E4
Bone Density
Alleles
Hip
Pelvic Bones
Calcaneus
Femur Neck
Bone Fractures
Photon Absorptiometry
Femur
Body Mass Index
Smoking

Cite this

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title = "Apolipoprotein E4 is Associated with Reduced Calcaneal Quantitative Ultrasound Measurements and Bone Mineral Density in Elderly Women",
abstract = "Some studies have reported an association between the apolipoprotein E4 (APOE4) allele and reduced bone density and increased propensity to fracture, but this remains controversial as other studies have not found an association between APOE4 and bone density or fracture. No information is available concerning the effect of the APOE4 allele on quantitative ultrasound (QUS) parameters. We therefore examined this issue in a population-based study of 1332 healthy elderly women, examining the effect of the APOE4 allele on QUS parameters at the calcaneus and comparing this to dual-energy X-ray absorptiometry (DEXA) bone mineral density (BNID) at the hip. In addition, we examined the effect of the APOE4 allele on fracture. Subjects who had at least one APOE4 allele (n = 308) had lower calcaneal QUS parameters and lower hip BNID at the total hip, trochanter, and intertrochanter, but not the femoral neck, compared to subjects without an APOE4 allele (n = 1024) after adjustment for age, body mass index (BMI), and smoking. The decrement in QUS parameters and BNID was approximately 2{\%}. Those subjects having an APOE4 allele were also more likely to fall into a low bone density group, defined by a T score of",
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Apolipoprotein E4 is Associated with Reduced Calcaneal Quantitative Ultrasound Measurements and Bone Mineral Density in Elderly Women. / Dick, Ian; Devine, A.; Marangou, Andrew; Dhaliwal, S.S.; Laws, S.; Martins, R.N.; Prince, Richard.

In: Bone, Vol. 31, No. 4, 2002, p. 497-502.

Research output: Contribution to journalArticle

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