Apolipoprotein B Metabolism: Tracer Kinetics, Models, and Metabolic Studies

    Research output: Contribution to journalArticlepeer-review

    39 Citations (Scopus)

    Abstract

    The study of apolipoprotein (apo) B metabolism is central to our understanding of lipoprotein metabolism. However, the assembly and secretion of apoB-containing lipoproteins is a complex process. Specialized techniques, developed and applied to in vitro and in vivo studies of apoB metabolism, have provided insights into the mechanisms involved in the regulation of this process. Moreover, these studies have important implications for understanding both the pathophysiology as well as the therapeutic options for the dyslipidemias. The purpose of this review is to examine the role of apoB in lipoprotein metabolism and to explore the applications of kinetic analysis and multicompartmental modeling to the study of apoB metabolism. New developments and significant advances over the last decade are discussed.
    Original languageEnglish
    Pages (from-to)89-137
    JournalCritical Reviews in Clinical Laboratory Sciences
    Volume39
    Issue number2
    DOIs
    Publication statusPublished - 2002

    Fingerprint

    Dive into the research topics of 'Apolipoprotein B Metabolism: Tracer Kinetics, Models, and Metabolic Studies'. Together they form a unique fingerprint.

    Cite this