TY - CHAP
T1 - Antiviral Mechanisms of Curcumin and Its Derivatives in Prevention and Treatment of COVID-19
T2 - A Review
AU - Golpour-Hamedani, Sahar
AU - Pourmasoumi, Makan
AU - Askari, Gholamreza
AU - Bagherniya, Mohammad
AU - Majeed, Muhammed
AU - Guest, Paul C.
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now plagued the world for almost 3 years. Although vaccines are now available, the severity of the pandemic and the current dearth of approved effective medications have prompted the need for novel treatment approaches. Curcumin, as a food nutraceutical with anti-inflammatory and antioxidant effects, is now under consideration for the prevention and treatment of COVID-19. Curcumin has been demonstrated to retard the entrance of SARS-CoV-2 into cells, interfere with its proliferation inside cells, and curb the hyperinflammatory state caused by the virus by modulating immune system regulators, minimizing the cytokine storm effect, and modulating the renin-angiotensin system. This chapter discusses the role of curcumin and its derivatives in the prevention and treatment of COVID-19 infection, considering the molecular mechanisms involved. It will also focus on the molecular and cellular profiling techniques as essential tools in this research, as these can be used in the identification and development of new biomarkers, drug targets, and therapeutic approaches for improved patient care.
AB - The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now plagued the world for almost 3 years. Although vaccines are now available, the severity of the pandemic and the current dearth of approved effective medications have prompted the need for novel treatment approaches. Curcumin, as a food nutraceutical with anti-inflammatory and antioxidant effects, is now under consideration for the prevention and treatment of COVID-19. Curcumin has been demonstrated to retard the entrance of SARS-CoV-2 into cells, interfere with its proliferation inside cells, and curb the hyperinflammatory state caused by the virus by modulating immune system regulators, minimizing the cytokine storm effect, and modulating the renin-angiotensin system. This chapter discusses the role of curcumin and its derivatives in the prevention and treatment of COVID-19 infection, considering the molecular mechanisms involved. It will also focus on the molecular and cellular profiling techniques as essential tools in this research, as these can be used in the identification and development of new biomarkers, drug targets, and therapeutic approaches for improved patient care.
KW - COVID-19
KW - Curcumin
KW - Nutraceutical
KW - Phytochemical
UR - http://www.scopus.com/inward/record.url?scp=85163576065&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-28012-2_21
DO - 10.1007/978-3-031-28012-2_21
M3 - Chapter
C2 - 37378779
AN - SCOPUS:85163576065
T3 - Advances in Experimental Medicine and Biology
SP - 397
EP - 411
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
