Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012

Y.X. Wang, Y.T. Xiang, Y.A. Su, Q. Li, L. Shu, C.H. Ng, Gabor Ungvari, H.F.K. Chiu, Y.P. Nin, G.H. Wang, P.S. Bai, T. Li, L.Z. Sun, J.G. Shi, X.S. Chen, Q.Y. Mei, K.Q. Li, X. Yu, T.M. Si

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    © 2015, Chinese Medical Association. All rights reserved. Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL). Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients’ socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection. Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P <0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups. Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients’ and relatives’ satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.
    Original languageEnglish
    Pages (from-to)1847-1852
    JournalChinese Medical Journal
    Volume128
    Issue number14
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Antipsychotic Agents
    China
    Quality of Life
    Depression
    Therapeutics
    Surveys and Questionnaires
    Delusions
    Hallucinations
    Psychiatric Hospitals
    Drug-Related Side Effects and Adverse Reactions
    Psychopathology
    Patient Satisfaction
    Antidepressive Agents
    Prescriptions
    Inpatients
    Logistic Models
    Regression Analysis
    Demography

    Cite this

    Wang, Y.X. ; Xiang, Y.T. ; Su, Y.A. ; Li, Q. ; Shu, L. ; Ng, C.H. ; Ungvari, Gabor ; Chiu, H.F.K. ; Nin, Y.P. ; Wang, G.H. ; Bai, P.S. ; Li, T. ; Sun, L.Z. ; Shi, J.G. ; Chen, X.S. ; Mei, Q.Y. ; Li, K.Q. ; Yu, X. ; Si, T.M. / Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012. In: Chinese Medical Journal. 2015 ; Vol. 128, No. 14. pp. 1847-1852.
    @article{8432226658b84080bd5e8c5d90213a69,
    title = "Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012",
    abstract = "{\circledC} 2015, Chinese Medical Association. All rights reserved. Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL). Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients’ socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection. Results: The frequency of antipsychotic use was 24.9{\%} in the whole sample; the corresponding figures were 17.1{\%}, 20.3{\%}, and 32.8{\%} in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P <0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups. Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients’ and relatives’ satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.",
    author = "Y.X. Wang and Y.T. Xiang and Y.A. Su and Q. Li and L. Shu and C.H. Ng and Gabor Ungvari and H.F.K. Chiu and Y.P. Nin and G.H. Wang and P.S. Bai and T. Li and L.Z. Sun and J.G. Shi and X.S. Chen and Q.Y. Mei and K.Q. Li and X. Yu and T.M. Si",
    year = "2015",
    doi = "10.4103/0366-6999.160485",
    language = "English",
    volume = "128",
    pages = "1847--1852",
    journal = "Chinese Medical Journal",
    issn = "0366-6999",
    publisher = "Chinese Medical Association",
    number = "14",

    }

    Wang, YX, Xiang, YT, Su, YA, Li, Q, Shu, L, Ng, CH, Ungvari, G, Chiu, HFK, Nin, YP, Wang, GH, Bai, PS, Li, T, Sun, LZ, Shi, JG, Chen, XS, Mei, QY, Li, KQ, Yu, X & Si, TM 2015, 'Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012' Chinese Medical Journal, vol. 128, no. 14, pp. 1847-1852. https://doi.org/10.4103/0366-6999.160485

    Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012. / Wang, Y.X.; Xiang, Y.T.; Su, Y.A.; Li, Q.; Shu, L.; Ng, C.H.; Ungvari, Gabor; Chiu, H.F.K.; Nin, Y.P.; Wang, G.H.; Bai, P.S.; Li, T.; Sun, L.Z.; Shi, J.G.; Chen, X.S.; Mei, Q.Y.; Li, K.Q.; Yu, X.; Si, T.M.

    In: Chinese Medical Journal, Vol. 128, No. 14, 2015, p. 1847-1852.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Antipsychotic medications in major depression and the association with treatment satisfaction and quality of life: Findings of three national surveys on use of psychotropics in China between 2002 and 2012

    AU - Wang, Y.X.

    AU - Xiang, Y.T.

    AU - Su, Y.A.

    AU - Li, Q.

    AU - Shu, L.

    AU - Ng, C.H.

    AU - Ungvari, Gabor

    AU - Chiu, H.F.K.

    AU - Nin, Y.P.

    AU - Wang, G.H.

    AU - Bai, P.S.

    AU - Li, T.

    AU - Sun, L.Z.

    AU - Shi, J.G.

    AU - Chen, X.S.

    AU - Mei, Q.Y.

    AU - Li, K.Q.

    AU - Yu, X.

    AU - Si, T.M.

    PY - 2015

    Y1 - 2015

    N2 - © 2015, Chinese Medical Association. All rights reserved. Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL). Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients’ socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection. Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P <0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups. Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients’ and relatives’ satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.

    AB - © 2015, Chinese Medical Association. All rights reserved. Background: Optimizing treatment outcomes for depression requires understanding of how evidence-based treatments are utilized in clinical practice. Antipsychotic medications concurrent with antidepressant treatment are frequently used in major depression, but few studies have investigated trends and patterns of their use over time. This study aimed to examine the prescription patterns of antipsychotic medications for major depression in China from 2002 to 2012 and their association with treatment satisfaction and quality of life (QOL). Methods: A total of 3655 subjects with major depression treated in 45 Chinese psychiatric hospitals/centers nationwide were interviewed between 2002 and 2012. Patients’ socio-demographic and clinical characteristics including psychopathology, medication side effects, satisfaction with treatment and QOL were recorded using a standardized protocol and data collection. Results: The frequency of antipsychotic use was 24.9% in the whole sample; the corresponding figures were 17.1%, 20.3%, and 32.8% in 2002, 2006, and 2012, respectively (χ2 = 90.3, df = 2, P <0.001). Multiple logistic regression analyses revealed that patients on concurrent antipsychotics had significantly more delusions or hallucinations, longer illness duration, greater side effects, and more likely to be treated as inpatients and in major hospitals (i.e., Level-III hospital). Antipsychotic use was associated with lower treatment satisfaction while there was no significant difference with respect to physical and mental QOL between the antipsychotic and nonantipsychotic groups. Conclusions: Concurrent antipsychotic use was found in about one in four treated depressed patients in China, which has increased over a 10-year period. Considering the association of drug-induced side effects and the lack of patients’ and relatives’ satisfaction with antipsychotic treatment, further examination of the rationale and appropriateness of the use of antipsychotics in depression is needed.

    U2 - 10.4103/0366-6999.160485

    DO - 10.4103/0366-6999.160485

    M3 - Article

    VL - 128

    SP - 1847

    EP - 1852

    JO - Chinese Medical Journal

    JF - Chinese Medical Journal

    SN - 0366-6999

    IS - 14

    ER -