Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues

Sing Yee Yeung, Matthew J. Piggott

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalFitoterapia
Volume123
DOIs
Publication statusPublished - 1 Nov 2017

Fingerprint

Antrodia
Biological Products
Fungi
Cell Line
Growth

Cite this

@article{a8408a1c4bd44999b5eb2786a3f5f712,
title = "Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues",
abstract = "Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.",
keywords = "4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, anticancer activity, Antrodia camphorata, NCI-60 screen",
author = "Yeung, {Sing Yee} and Piggott, {Matthew J.}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.fitote.2017.08.019",
language = "English",
volume = "123",
pages = "9--12",
journal = "Ghisalberti, E.L., The Goodeniaceae",
issn = "1971-551X",
publisher = "Pergamon",

}

TY - JOUR

T1 - Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues

AU - Yeung, Sing Yee

AU - Piggott, Matthew J.

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.

AB - Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.

KW - 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole

KW - anticancer activity

KW - Antrodia camphorata

KW - NCI-60 screen

UR - http://www.scopus.com/inward/record.url?scp=85029805582&partnerID=8YFLogxK

U2 - 10.1016/j.fitote.2017.08.019

DO - 10.1016/j.fitote.2017.08.019

M3 - Article

VL - 123

SP - 9

EP - 12

JO - Ghisalberti, E.L., The Goodeniaceae

JF - Ghisalberti, E.L., The Goodeniaceae

SN - 1971-551X

ER -