Antiproliferative activity of the Antrodia camphorata secondary metabolite 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole and analogues

Sing Yee Yeung, Matthew J. Piggott

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d][1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 μM, none had sufficient activity to warrant further investigation.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalFitoterapia
Volume123
DOIs
Publication statusPublished - 1 Nov 2017

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