Antiplasmodial and Antioxidant Isofuranonaphthoquinones from the roots of Bulbine capitata

M. Bezabih, B.M. Abegaz, K. Dufall, Kevin Croft, T. Skinner-Adams, Timothy Davis

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1 -tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10'-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2.3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2.3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.
Original languageEnglish
Pages (from-to)340-344
JournalPlanta Medica
Volume67
DOIs
Publication statusPublished - 2001

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