Antimicrobial resistance in Clostridium difficile ribotype 017

Korakrit Imwattana, Daniel R. Knight, Brian Kullin, Deirdre A. Collins, Papanin Putsathit, Pattarachai Kiratisin, Thomas V. Riley

Research output: Contribution to journalReview article

Abstract

Introduction: Antimicrobial resistance (AMR) played an important role in the initial outbreaks of Clostridium difficile infection (CDI) in the 1970s. C. difficile ribotype (RT) 017 has emerged as the major strain of C. difficile in Asia, where antimicrobial use is poorly regulated. This strain has also caused CDI outbreaks around the world for almost 30 years. Many of these outbreaks were associated with clindamycin and fluoroquinolone resistance. AMR and selective pressure is likely to be responsible for the success of this RT and may drive future outbreaks. Areas covered: This narrative review summarizes the prevalence and mechanisms of AMR in C. difficile RT 017 and transmission of these AMR mechanisms. To address these topics, reports of outbreaks due to C. difficile RT 017, epidemiologic studies with antimicrobial susceptibility results, studies on resistance mechanisms found in C. difficile and related publications available through Pubmed until September 2019 were collated and the findings discussed. Expert opinion: Primary prevention is the key to control CDI. This should be achieved by developing antimicrobial stewardship in medical, veterinary and agricultural practices. AMR is the key factor that drives CDI outbreaks, and methods for the early detection of AMR can facilitate the control of outbreaks.

Original languageEnglish
Pages (from-to)17-25
JournalExpert Review of Anti-infective Therapy
Volume18
Issue number1
DOIs
Publication statusPublished - 2020

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Ribotyping
Clostridium difficile
Disease Outbreaks
Clostridium Infections
Clindamycin
Fluoroquinolones
Expert Testimony
Primary Prevention
PubMed
Epidemiologic Studies

Cite this

Imwattana, Korakrit ; Knight, Daniel R. ; Kullin, Brian ; Collins, Deirdre A. ; Putsathit, Papanin ; Kiratisin, Pattarachai ; Riley, Thomas V. / Antimicrobial resistance in Clostridium difficile ribotype 017. In: Expert Review of Anti-infective Therapy. 2020 ; Vol. 18, No. 1. pp. 17-25.
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Antimicrobial resistance in Clostridium difficile ribotype 017. / Imwattana, Korakrit; Knight, Daniel R.; Kullin, Brian; Collins, Deirdre A.; Putsathit, Papanin; Kiratisin, Pattarachai; Riley, Thomas V.

In: Expert Review of Anti-infective Therapy, Vol. 18, No. 1, 2020, p. 17-25.

Research output: Contribution to journalReview article

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AU - Kiratisin, Pattarachai

AU - Riley, Thomas V.

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