Antimicrobial resistance in Clostridioides difficile

Keeley O’Grady; Daniel R. Knight; Thomas V. Riley

doi:10.1007/s10096-021-04311-5

Antimicrobial resistance in Clostridioides difficile

Keeley O’Grady, Daniel R. Knight, Thomas V. Riley

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLS_B-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

Original language	English
Pages (from-to)	2459-2478
Number of pages	20
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	40
Issue number	12
Early online date	24 Aug 2021
DOIs	https://doi.org/10.1007/s10096-021-04311-5
Publication status	Published - Dec 2021

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title = "Antimicrobial resistance in Clostridioides difficile",

abstract = "Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.",

keywords = "Antimicrobial resistance, Clostridioides difficile, Epidemiology, Genetics, Genome, Phenotype",

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T1 - Antimicrobial resistance in Clostridioides difficile

AU - O’Grady, Keeley

AU - Knight, Daniel R.

AU - Riley, Thomas V.

PY - 2021/12

Y1 - 2021/12

N2 - Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

AB - Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

KW - Antimicrobial resistance

KW - Clostridioides difficile

KW - Epidemiology

KW - Genetics

KW - Genome

KW - Phenotype

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U2 - 10.1007/s10096-021-04311-5

DO - 10.1007/s10096-021-04311-5

M3 - Review article

C2 - 34427801

AN - SCOPUS:85113369668

SN - 0934-9723

VL - 40

SP - 2459

EP - 2478

JO - European Journal of Clinical Microbiology and Infectious Diseases

JF - European Journal of Clinical Microbiology and Infectious Diseases

IS - 12

ER -

Antimicrobial resistance in Clostridioides difficile

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