Antigens in breast milk: possible impact on immune system education

Research output: Chapter in Book/Conference paperChapter

Abstract

Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing, requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non 'dangerous' antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. Better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.

Original languageEnglish
Title of host publicationHandbook of dietary and nutritional aspects of human breast milk
EditorsS Zibadi, RR Watson, VR Preedy
Place of PublicationNetherlands
PublisherWageningen Academic Publishers
Pages447-459
Number of pages13
Volume5
ISBN (Electronic)9789086867646
ISBN (Print)9789086862092
DOIs
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameHuman Health Handbooks
PublisherWageningen Academic Publishers
ISSN (Print)2212-375X

Cite this

Macchiaverni, P., Tulic, M. K., & Verhasselt, V. (2013). Antigens in breast milk: possible impact on immune system education. In S. Zibadi, RR. Watson, & VR. Preedy (Eds.), Handbook of dietary and nutritional aspects of human breast milk (Vol. 5, pp. 447-459). (Human Health Handbooks). Netherlands: Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-764-6_25
Macchiaverni, P. ; Tulic, M. K. ; Verhasselt, V. / Antigens in breast milk : possible impact on immune system education. Handbook of dietary and nutritional aspects of human breast milk. editor / S Zibadi ; RR Watson ; VR Preedy. Vol. 5 Netherlands : Wageningen Academic Publishers, 2013. pp. 447-459 (Human Health Handbooks).
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Macchiaverni, P, Tulic, MK & Verhasselt, V 2013, Antigens in breast milk: possible impact on immune system education. in S Zibadi, RR Watson & VR Preedy (eds), Handbook of dietary and nutritional aspects of human breast milk. vol. 5, Human Health Handbooks, Wageningen Academic Publishers, Netherlands, pp. 447-459. https://doi.org/10.3920/978-90-8686-764-6_25

Antigens in breast milk : possible impact on immune system education. / Macchiaverni, P.; Tulic, M. K.; Verhasselt, V.

Handbook of dietary and nutritional aspects of human breast milk. ed. / S Zibadi; RR Watson; VR Preedy. Vol. 5 Netherlands : Wageningen Academic Publishers, 2013. p. 447-459 (Human Health Handbooks).

Research output: Chapter in Book/Conference paperChapter

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AU - Verhasselt, V.

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AB - Neonatal immune system faces considerable challenges as it must cope with antigenic stimulus following gut and skin bacterial colonization, and exposure to numerous new environmental antigens while organs are developing, requiring low inflammation to allow harmonious growth. In addition to its impact on child growth and prevention of infectious disease, breast-milk may help to educate the immune system towards acceptance of non 'dangerous' antigens. Indeed, epidemiological studies report that breastfeeding protects from immune-mediated diseases such as allergy, celiac disease and type-1 Diabetes. However, data are controversial and mechanisms unclear. Here we will present and discuss experimental data indicating that breastfeeding-induced protection may rely on immune tolerance induction in the breastfed child upon antigen transfer through maternal milk. The tolerogenic potential of breast milk depends on maternal exposure to common environmental and dietary antigens and the efficiency of antigen transfer across mammary epithelium. Induction of tolerance upon breast-milk mediated antigen transfer will also depend on the presence of immunomodulatory factors in breast-milk and of its impact on neonatal gut and immune system maturation. Better understanding of maternal influence on tolerance induction by antigen transfer through breast milk should allow the development of new strategies for prevention of immune mediated diseases.

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KW - INHALED ANTIGEN

KW - MATERNAL INTAKE

KW - ORAL TOLERANCE

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SN - 9789086862092

VL - 5

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SP - 447

EP - 459

BT - Handbook of dietary and nutritional aspects of human breast milk

A2 - Zibadi, S

A2 - Watson, RR

A2 - Preedy, VR

PB - Wageningen Academic Publishers

CY - Netherlands

ER -

Macchiaverni P, Tulic MK, Verhasselt V. Antigens in breast milk: possible impact on immune system education. In Zibadi S, Watson RR, Preedy VR, editors, Handbook of dietary and nutritional aspects of human breast milk. Vol. 5. Netherlands: Wageningen Academic Publishers. 2013. p. 447-459. (Human Health Handbooks). https://doi.org/10.3920/978-90-8686-764-6_25