Antigen-Based Vaccination and Prevention of Type 1 Diabetes

L.C. Harrison; J.M. Wentworth; Y. Zhang; E. Bandala-Sanchez; R.M. Böhmer; A.M. Neale; N.L. Stone; G. Naselli; J.J. Bosco; P. Auyeung; M. Rashidi; P. Augstein; Grant Morahan

doi:10.1007/s11892-013-0415-7

Antigen-Based Vaccination and Prevention of Type 1 Diabetes

L.C. Harrison, J.M. Wentworth, Y. Zhang, E. Bandala-Sanchez, R.M. Böhmer, A.M. Neale, N.L. Stone, G. Naselli, J.J. Bosco, P. Auyeung, M. Rashidi, P. Augstein, Grant Morahan

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34 Citations (Scopus)

Abstract

Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle–dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.

Original language	English
Pages (from-to)	616-623
Number of pages	8
Journal	Current Diabetes Reports
Volume	13
Early online date	27 Jul 2013
DOIs	https://doi.org/10.1007/s11892-013-0415-7
Publication status	Published - Oct 2013
Externally published	Yes

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title = "Antigen-Based Vaccination and Prevention of Type 1 Diabetes",

abstract = "Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle–dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.",

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AU - Harrison, L.C.

AU - Wentworth, J.M.

AU - Zhang, Y.

AU - Bandala-Sanchez, E.

AU - Böhmer, R.M.

AU - Neale, A.M.

AU - Stone, N.L.

AU - Naselli, G.

AU - Bosco, J.J.

AU - Auyeung, P.

AU - Rashidi, M.

AU - Augstein, P.

AU - Morahan, Grant

PY - 2013/10

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N2 - Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle–dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.

AB - Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before the onset of symptoms, and autoimmune diabetes is preventable in rodent models. Intervention in asymptomatic individuals before or after the onset of subclinical islet autoimmunity places a premium on safety, a requirement met only by lifestyle–dietary approaches or autoantigen-based vaccination to induce protective immune tolerance. Insulin is the key driver of autoimmune β-cell destruction in the nonobese diabetic (NOD) mouse model of T1D and is an early autoimmune target in children at risk for T1D. In the NOD mouse, mucosal administration of insulin induces regulatory T cells that protect against diabetes. The promise of autoantigen-specific vaccination in humans has yet to be realized, but recent trials of oral and nasal insulin vaccination in at-risk humans provide grounds for cautious optimism.

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SN - 1534-4827

VL - 13

SP - 616

EP - 623

JO - Current Diabetes Reports

JF - Current Diabetes Reports

ER -

Antigen-Based Vaccination and Prevention of Type 1 Diabetes

Abstract

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