Antifungal Metabolites From Trichoderma harzianum

Emilio Ghisalberti, C.Y. Rowland

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)


A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7,8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.
Original languageEnglish
Pages (from-to)1799-1804
JournalJournal of Natural Products
Issue number10
Publication statusPublished - 1993


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