Antifungal Metabolites From Trichoderma harzianum

Emilio Ghisalberti; C.Y. Rowland

doi:10.1021/np50100a020

Antifungal Metabolites From Trichoderma harzianum

Emilio Ghisalberti, C.Y. Rowland

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

119 Citations (Scopus)

Abstract

A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7,8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.

Original language	English
Pages (from-to)	1799-1804
Journal	Journal of Natural Products
Volume	56
Issue number	10
DOIs	https://doi.org/10.1021/np50100a020
Publication status	Published - 1993

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title = "Antifungal Metabolites From Trichoderma harzianum",

abstract = "A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7,8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.",

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AB - A detailed examination of the metabolites produced in liquid cultures by a strain of Trichoderma harzianum, isolated from wheat roots, has resulted in the identification of a further five metabolites. Two of these, cyclonerodiol [5] and the octaketide keto diol 6, have previously been isolated from a strain of Trichoderma koningii. The structures of the three new octaketide-derived compounds 7,8, and 10 have been deduced from spectroscopic and chemical studies. All newly isolated compounds show antibiotic activity towards the take-all fungus, Gaeumannomyces graminis var. tritici.

U2 - 10.1021/np50100a020

DO - 10.1021/np50100a020

M3 - Article

VL - 56

SP - 1799

EP - 1804

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Antifungal Metabolites From Trichoderma harzianum

Abstract

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