TY - JOUR
T1 - Anticancer Mechanisms of Berberine
T2 - A Good Choice for Glioblasto-ma Multiforme Therapy
AU - Bibak, Bahram
AU - Shakeri, Farzaneh
AU - Keshavarzi, Zakieh
AU - Mollazadeh, Hamid
AU - Javid, Hossein
AU - Jalili-Nik, Mohammad
AU - Sathyapalan, Thozhukat
AU - Afshari, Amir R.
AU - Sahebkar, Amirhossein
PY - 2022/4/6
Y1 - 2022/4/6
N2 - The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by regulating several signaling pathways. Berberine, an isoquinoline alkaloid, has various pharmacological applications to combat severe diseases like cancer. Mechanistically, it inhibits cell proliferation and invasion, suppresses tumor angiogenesis, and induces cell apoptosis. The antitumoral effect of berberine in GBM is increasingly recognized. This review sheds new light on the regulatory signaling mechanisms of berberine in various cancers, proposing its potential role as a therapeutic agent for GBM.
AB - The most typical malignant brain tumor, glioblastoma multiforme (GBM), seems to have a grim outcome, despite the intensive multi-modality interventions. Literature suggests that biologically active phytomolecules may exert anticancer properties by regulating several signaling pathways. Berberine, an isoquinoline alkaloid, has various pharmacological applications to combat severe diseases like cancer. Mechanistically, it inhibits cell proliferation and invasion, suppresses tumor angiogenesis, and induces cell apoptosis. The antitumoral effect of berberine in GBM is increasingly recognized. This review sheds new light on the regulatory signaling mechanisms of berberine in various cancers, proposing its potential role as a therapeutic agent for GBM.
KW - apoptosis
KW - autophagy
KW - berberine
KW - Glioblastoma multiforme
KW - malignant brain tumor
KW - phytomolecules
UR - http://www.scopus.com/inward/record.url?scp=85131861649&partnerID=8YFLogxK
U2 - 10.2174/0929867329666220224112811
DO - 10.2174/0929867329666220224112811
M3 - Review article
C2 - 35209812
AN - SCOPUS:85131861649
SN - 0929-8673
VL - 29
SP - 4507
EP - 4528
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
IS - 26
ER -
