Anticancer compounds from Western Australian marine sponges

Sumi Shrestha

Research output: ThesisDoctoral Thesis

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Abstract

Triple negative breast cancer (TNBC) is a subtype of breast cancers that lacks effective targeted therapy and has poor clinical outcomes. Hence, new strategies are needed for treating TNBC. Marine sponges have historically been a source of anticancer compounds and sponges from the Western Australian coast have so far received little attention. Thus, this study focused on screening WA marine sponges for cytotoxic activity in TNBC. Bioassay-guided fractionation of two active sponges Monanchoraviridis and Manihinea lynbeazleyae resulted in isolation of crambescidin 800 and aurantoside C as active compounds, which were also investigated for their mechanism of action in TNBC.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date14 Oct 2019
DOIs
Publication statusUnpublished - 2019

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Triple Negative Breast Neoplasms
Porifera
Biological Assay
Breast Neoplasms

Cite this

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abstract = "Triple negative breast cancer (TNBC) is a subtype of breast cancers that lacks effective targeted therapy and has poor clinical outcomes. Hence, new strategies are needed for treating TNBC. Marine sponges have historically been a source of anticancer compounds and sponges from the Western Australian coast have so far received little attention. Thus, this study focused on screening WA marine sponges for cytotoxic activity in TNBC. Bioassay-guided fractionation of two active sponges Monanchoraviridis and Manihinea lynbeazleyae resulted in isolation of crambescidin 800 and aurantoside C as active compounds, which were also investigated for their mechanism of action in TNBC.",
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Shrestha, S 2019, 'Anticancer compounds from Western Australian marine sponges', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.26182/5dccd7040e0e1

Anticancer compounds from Western Australian marine sponges. / Shrestha, Sumi.

2019.

Research output: ThesisDoctoral Thesis

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T1 - Anticancer compounds from Western Australian marine sponges

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PY - 2019

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N2 - Triple negative breast cancer (TNBC) is a subtype of breast cancers that lacks effective targeted therapy and has poor clinical outcomes. Hence, new strategies are needed for treating TNBC. Marine sponges have historically been a source of anticancer compounds and sponges from the Western Australian coast have so far received little attention. Thus, this study focused on screening WA marine sponges for cytotoxic activity in TNBC. Bioassay-guided fractionation of two active sponges Monanchoraviridis and Manihinea lynbeazleyae resulted in isolation of crambescidin 800 and aurantoside C as active compounds, which were also investigated for their mechanism of action in TNBC.

AB - Triple negative breast cancer (TNBC) is a subtype of breast cancers that lacks effective targeted therapy and has poor clinical outcomes. Hence, new strategies are needed for treating TNBC. Marine sponges have historically been a source of anticancer compounds and sponges from the Western Australian coast have so far received little attention. Thus, this study focused on screening WA marine sponges for cytotoxic activity in TNBC. Bioassay-guided fractionation of two active sponges Monanchoraviridis and Manihinea lynbeazleyae resulted in isolation of crambescidin 800 and aurantoside C as active compounds, which were also investigated for their mechanism of action in TNBC.

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KW - natural product

KW - triple negative breast cancer

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DO - 10.26182/5dccd7040e0e1

M3 - Doctoral Thesis

ER -