Antibody responses against influenza A decline with successive years of annual influenza vaccination

Sheena G. Sullivan; Arseniy Khvorov; Louise Carolan; Leslie Dowson; A. Jessica Hadiprodjo; Stephany Sánchez-Ovando; Yi Liu; Vivian K.Y. Leung; David Hodgson; Christopher C. Blyth; Marion Macnish; Allen C. Cheng; Michelle Haugenauer; Julia Clark; Sonia Dougherty; Kristine Macartney; Archana Koirala; Ameneh Khatami; Ajay Jadhav; Helen Marshall; Kathryn E. Riley; Peter A.B. Wark; Catherine Delahunty; Kanta Subbarao; Adam J. Kucharski; Annette Fox

doi:10.1038/s41541-024-01057-x

Antibody responses against influenza A decline with successive years of annual influenza vaccination

Sheena G. Sullivan, Arseniy Khvorov, Louise Carolan, Leslie Dowson, A. Jessica Hadiprodjo, Stephany Sánchez-Ovando, Yi Liu, Vivian K.Y. Leung, David Hodgson, Christopher C. Blyth, Marion Macnish, Allen C. Cheng, Michelle Haugenauer, Julia Clark, Sonia Dougherty, Kristine Macartney, Archana Koirala, Ameneh Khatami, Ajay Jadhav, Helen MarshallKathryn E. Riley, Peter A.B. Wark, Catherine Delahunty, Kanta Subbarao, Adam J. Kucharski, Annette Fox

Paediatrics

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.

Original language	English
Article number	11
Number of pages	10
Journal	npj Vaccines
Volume	10
DOIs	https://doi.org/10.1038/s41541-024-01057-x
Publication status	Published - 17 Jan 2025

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Sullivan, S. G., Khvorov, A., Carolan, L., Dowson, L., Hadiprodjo, A. J., Sánchez-Ovando, S., Liu, Y., Leung, V. K. Y., Hodgson, D., Blyth, C. C., Macnish, M., Cheng, A. C., Haugenauer, M., Clark, J., Dougherty, S., Macartney, K., Koirala, A., Khatami, A., Jadhav, A., ... Fox, A. (2025). Antibody responses against influenza A decline with successive years of annual influenza vaccination. npj Vaccines, 10, Article 11. https://doi.org/10.1038/s41541-024-01057-x

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title = "Antibody responses against influenza A decline with successive years of annual influenza vaccination",

abstract = "Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and \textasciitilde{}14 and \textasciitilde{}180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5\% had not been vaccinated during five years prior to enrolment and 55\% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.",

author = "Sullivan, \{Sheena G.\} and Arseniy Khvorov and Louise Carolan and Leslie Dowson and Hadiprodjo, \{A. Jessica\} and Stephany S{\'a}nchez-Ovando and Yi Liu and Leung, \{Vivian K.Y.\} and David Hodgson and Blyth, \{Christopher C.\} and Marion Macnish and Cheng, \{Allen C.\} and Michelle Haugenauer and Julia Clark and Sonia Dougherty and Kristine Macartney and Archana Koirala and Ameneh Khatami and Ajay Jadhav and Helen Marshall and Riley, \{Kathryn E.\} and Wark, \{Peter A.B.\} and Catherine Delahunty and Kanta Subbarao and Kucharski, \{Adam J.\} and Annette Fox",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = jan,

day = "17",

doi = "10.1038/s41541-024-01057-x",

language = "English",

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Sullivan, SG, Khvorov, A, Carolan, L, Dowson, L, Hadiprodjo, AJ, Sánchez-Ovando, S, Liu, Y, Leung, VKY, Hodgson, D, Blyth, CC, Macnish, M, Cheng, AC, Haugenauer, M, Clark, J, Dougherty, S, Macartney, K, Koirala, A, Khatami, A, Jadhav, A, Marshall, H, Riley, KE, Wark, PAB, Delahunty, C, Subbarao, K, Kucharski, AJ & Fox, A 2025, 'Antibody responses against influenza A decline with successive years of annual influenza vaccination', npj Vaccines, vol. 10, 11. https://doi.org/10.1038/s41541-024-01057-x

TY - JOUR

T1 - Antibody responses against influenza A decline with successive years of annual influenza vaccination

AU - Sullivan, Sheena G.

AU - Khvorov, Arseniy

AU - Carolan, Louise

AU - Dowson, Leslie

AU - Hadiprodjo, A. Jessica

AU - Sánchez-Ovando, Stephany

AU - Liu, Yi

AU - Leung, Vivian K.Y.

AU - Hodgson, David

AU - Blyth, Christopher C.

AU - Macnish, Marion

AU - Cheng, Allen C.

AU - Haugenauer, Michelle

AU - Clark, Julia

AU - Dougherty, Sonia

AU - Macartney, Kristine

AU - Koirala, Archana

AU - Khatami, Ameneh

AU - Jadhav, Ajay

AU - Marshall, Helen

AU - Riley, Kathryn E.

AU - Wark, Peter A.B.

AU - Delahunty, Catherine

AU - Subbarao, Kanta

AU - Kucharski, Adam J.

AU - Fox, Annette

PY - 2025/1/17

Y1 - 2025/1/17

N2 - Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.

AB - Influenza vaccine effectiveness and immunogenicity can be compromised with repeated vaccination. We assessed immunological markers in a cohort of healthcare workers (HCW) from six public hospitals around Australia during 2020–2021. Sera were collected pre-vaccination and ~14 and ~180 days post-vaccination and assessed in haemagglutination inhibition assay against egg-grown vaccine and equivalent cell-grown viruses. Responses to vaccination were compared by the number of prior vaccinations. Baseline sera were available for 595 HCW in 2020 and 1031 in 2021. 5% had not been vaccinated during five years prior to enrolment and 55% had been vaccinated every year. Post-vaccination titres for all vaccine antigens were lowest among HCW vaccinated in all 5-prior years and highest among HCW with 0 or 1 prior vaccinations, even after adjustment. This was observed for both influenza A subtypes and was dependent on pre-vaccination titre. Expanded cohorts are needed to better understand how this translates to vaccine effectiveness.

UR - https://www.scopus.com/pages/publications/85217742348

U2 - 10.1038/s41541-024-01057-x

DO - 10.1038/s41541-024-01057-x

M3 - Article

C2 - 39820465

AN - SCOPUS:85217742348

SN - 2059-0105

VL - 10

JO - npj Vaccines

JF - npj Vaccines

M1 - 11

ER -

Antibody responses against influenza A decline with successive years of annual influenza vaccination

Abstract

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