Abstract
Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses of global health significance. This thesis investigated antibody responses in West Australian travellers 9 days to 6 years after infection with contemporaneous, circulating DENV and ZIKV. Anti-DENV serotype cross-reactivity restricted over time to become increasingly serotype-specific however strain-specific heterologous cross-neutralisation was maintained at 6 years. Magnitude of anti-ZIKV responses declined over time in monotypic ZIKV infection but persisted in flavivirus-infected or immunised individuals. Anti-ZIKV capsid/prM can differentiate recent ZIKV infection from previous DENV infection. Acute but not convalescent phase anti-DENV antibody enhanced ZIKV replication. Implications for vaccine design are discussed.
| Original language | English |
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| Qualification | Doctor of Philosophy |
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| Award date | 26 Jun 2018 |
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| Publication status | Unpublished - 2018 |
Access to Document
- THESIS - DOCTOR OF PHILOSOPHY - PANTA Kritu - 2018
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