Antibody mediated immune response against Flavivirus infection in West Australian travellers

Research output: ThesisDoctoral Thesis

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Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses of global health significance. This thesis investigated antibody responses in West Australian travellers 9 days to 6 years after infection with contemporaneous, circulating DENV and ZIKV. Anti-DENV serotype cross-reactivity restricted over time to become increasingly serotype-specific however strain-specific heterologous cross-neutralisation was maintained at 6 years. Magnitude of anti-ZIKV responses declined over time in monotypic ZIKV infection but persisted in flavivirus-infected or immunised individuals. Anti-ZIKV capsid/prM can differentiate recent ZIKV infection from previous DENV infection. Acute but not convalescent phase anti-DENV antibody enhanced ZIKV replication. Implications for vaccine design are discussed.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
  • Imrie, Allison, Supervisor
  • Smith, David, Supervisor
  • French, Martyn, Supervisor
  • De Klerk, Nicholas, Supervisor
Award date26 Jun 2018
Publication statusUnpublished - 2018


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