Dengue virus (DENV) and Zika virus (ZIKV) are flaviviruses of global health significance. This thesis investigated antibody responses in West Australian travellers 9 days to 6 years after infection with contemporaneous, circulating DENV and ZIKV. Anti-DENV serotype cross-reactivity restricted over time to become increasingly serotype-specific however strain-specific heterologous cross-neutralisation was maintained at 6 years. Magnitude of anti-ZIKV responses declined over time in monotypic ZIKV infection but persisted in flavivirus-infected or immunised individuals. Anti-ZIKV capsid/prM can differentiate recent ZIKV infection from previous DENV infection. Acute but not convalescent phase anti-DENV antibody enhanced ZIKV replication. Implications for vaccine design are discussed.
|Qualification||Doctor of Philosophy|
|Award date||26 Jun 2018|
|Publication status||Unpublished - 2018|