Antibodies to Seasonal Coronaviruses Rarely Cross-React with SARS-CoV-2: Findings from an African Birth Cohort

Heather J Zar, Mark P Nicol, Rae MacGinty, Lesley Workman, Wonita Petersen, Marina Johnson, David Goldblatt

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Antibodies to seasonal human-coronaviruses (sHCoV) may cross-protect against SARS-CoV-2. We investigated antibody responses in biobanked serum obtained before the pandemic from infants with polymerase chain reaction-confirmed sHCoV. Among 141 samples with antibodies to sHCoV, 4 (2.8%) were positive for SARS-CoV-2-S1 and 8 (5.7%) for SARS-CoV-2-S2. Antibodies to sHCoV rarely cross-react with SARS-CoV-2 antigens and are unlikely to account for mild pediatric illness.

Original languageEnglish
Pages (from-to)e516-e519
JournalThe Pediatric Infectious Disease Journal
Volume40
Issue number12
DOIs
Publication statusPublished - 1 Dec 2021

Fingerprint

Dive into the research topics of 'Antibodies to Seasonal Coronaviruses Rarely Cross-React with SARS-CoV-2: Findings from an African Birth Cohort'. Together they form a unique fingerprint.

Cite this