Anti-neutrophil cytoplasmic antibody associated vasculitis of the brain and oral cavity: a case report

Daniel Bontempo, Agnieszka Frydrych, Omar Kujan, D. Gebauer, M. Fallon, P.K. Panegyres

Research output: Contribution to journalArticlepeer-review


We report a patient with a novel presentation of anti-neutrophil cytoplasmic antibody positive(ANCA+) vasculitis of the brain and oral mucosa. ANCA+ vasculitis of the brain is usually associated with pachymeningitis and hypophysitis, and there are no cases reported with simultaneous brain and oral mucosal involvement.A35-year-old African Zambian man presented with headache and bleeding swollen gingiva. He was myeloperoxidase (MPO) antibody positive with cytoplasmic staining. His MRI showed stable small callosal, periventricular and subcortical white matter non-enhancing lesions, without changeover 15months—compatible with vasculitis. His gingival biopsy was consistent with vasculitis. His headache and oral lesions responded to oral corticosteroids and intravenous immunoglobulin which have induced clinical remission. Our patient expands the clinical syndrome of ANCA+MPO+C-type vasculitis of the central nervous system with headaches complicating cerebral vasculitis and oral mucosal involvement.
Original languageEnglish
Article numberomad100
Pages (from-to)343-345
JournalOxford Medical Case Reports
Issue number9
Publication statusPublished - 2023


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