Anti-inflammatory therapies for bronchopulmonary dysplasia

Paris Clarice Papagianis

Research output: ThesisDoctoral Thesis

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Abstract

Bronchopulmonary dysplasia (BPD) is a chronic lung disease that represents the principal cause of morbidity in extremely preterm infants. There is no therapy for BPD.
'BPD is defined as the requirement for respiratory support for at least 28 days. BPD is characterised by lung inflammation. Prevention or attenuation of inflammation offers a realistic therapeutic for BPD.
We utilised low-dose postnatal steroids and human amnion epithelial cells (hAECs) in separate studies to prevent inflammation and BPD-like pathology in preterm lambs. We show low-dose postnatal steroids reduce lung inflammation, while hAECs augment lung inflammation. Neither therapy reduced ventilator requirements in preterm lambs.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date15 Feb 2019
DOIs
Publication statusUnpublished - 2019

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Bronchopulmonary Dysplasia
Anti-Inflammatory Agents
Pneumonia
Amnion
Therapeutics
Epithelial Cells
Steroids
Extremely Premature Infants
Inflammation
Mechanical Ventilators
Lung Diseases
Chronic Disease
Pathology
Morbidity

Cite this

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title = "Anti-inflammatory therapies for bronchopulmonary dysplasia",
abstract = "Bronchopulmonary dysplasia (BPD) is a chronic lung disease that represents the principal cause of morbidity in extremely preterm infants. There is no therapy for BPD. 'BPD is defined as the requirement for respiratory support for at least 28 days. BPD is characterised by lung inflammation. Prevention or attenuation of inflammation offers a realistic therapeutic for BPD. We utilised low-dose postnatal steroids and human amnion epithelial cells (hAECs) in separate studies to prevent inflammation and BPD-like pathology in preterm lambs. We show low-dose postnatal steroids reduce lung inflammation, while hAECs augment lung inflammation. Neither therapy reduced ventilator requirements in preterm lambs.",
keywords = "pulmonary, Inflammation, Chorioamnionitis, Glucocorticoid, bonchopulmonary dysplasia, human amnion epithelial cells",
author = "Papagianis, {Paris Clarice}",
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language = "English",
school = "The University of Western Australia",

}

Papagianis, PC 2019, 'Anti-inflammatory therapies for bronchopulmonary dysplasia', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.26182/5c92fa2fe5c1d

Anti-inflammatory therapies for bronchopulmonary dysplasia. / Papagianis, Paris Clarice.

2019.

Research output: ThesisDoctoral Thesis

TY - THES

T1 - Anti-inflammatory therapies for bronchopulmonary dysplasia

AU - Papagianis, Paris Clarice

PY - 2019

Y1 - 2019

N2 - Bronchopulmonary dysplasia (BPD) is a chronic lung disease that represents the principal cause of morbidity in extremely preterm infants. There is no therapy for BPD. 'BPD is defined as the requirement for respiratory support for at least 28 days. BPD is characterised by lung inflammation. Prevention or attenuation of inflammation offers a realistic therapeutic for BPD. We utilised low-dose postnatal steroids and human amnion epithelial cells (hAECs) in separate studies to prevent inflammation and BPD-like pathology in preterm lambs. We show low-dose postnatal steroids reduce lung inflammation, while hAECs augment lung inflammation. Neither therapy reduced ventilator requirements in preterm lambs.

AB - Bronchopulmonary dysplasia (BPD) is a chronic lung disease that represents the principal cause of morbidity in extremely preterm infants. There is no therapy for BPD. 'BPD is defined as the requirement for respiratory support for at least 28 days. BPD is characterised by lung inflammation. Prevention or attenuation of inflammation offers a realistic therapeutic for BPD. We utilised low-dose postnatal steroids and human amnion epithelial cells (hAECs) in separate studies to prevent inflammation and BPD-like pathology in preterm lambs. We show low-dose postnatal steroids reduce lung inflammation, while hAECs augment lung inflammation. Neither therapy reduced ventilator requirements in preterm lambs.

KW - pulmonary

KW - Inflammation

KW - Chorioamnionitis

KW - Glucocorticoid

KW - bonchopulmonary dysplasia

KW - human amnion epithelial cells

U2 - 10.26182/5c92fa2fe5c1d

DO - 10.26182/5c92fa2fe5c1d

M3 - Doctoral Thesis

ER -