TY - JOUR
T1 - Anti-arthritic and Antioxidant Effects of Trehalose in an Experimental Model of Arthritis
AU - Forouzanfar, Fatemeh
AU - Vakilzadeh, Mohammad Moein
AU - Mehri, Ali
AU - Pourbagher-Shahri, Ali Mohammad
AU - Ganjali, Shiva
AU - Abbasifard, Mitra
AU - Sahebkar, Amirhossein
PY - 2023/9/11
Y1 - 2023/9/11
N2 - Background: The purpose of the present study was to study the potential anti-arthritic and antioxidant effects of trehalose in an experimental model of complete Freund’s adjuvant (CFA)-induced arthritis. Methods: Arthritis was induced via subcutaneous injection of CFA (0.1) into the right footpad of each rat. Trehalose (10 mg/kg per day) and indomethacin (5 mg/kg) as a reference drug were in-traperitoneally injected into CFA-induced arthritic rats from days 0 to 21. Changes in paw volume, pain responses, arthritic score, and oxidative/antioxidative parameters were determined. Results: Trehalose administration could significantly decrease arthritis scores (p <0.01) and paw edema (p <0.001), and significantly increase the nociceptive threshold (p <0.05) in CFA-induced arthritic rats. Trehalose also significantly reduced the pro-oxidant-antioxidant balance values when compared to CFA treatment alone. In addition, no significant difference was found between the trehalose group and indomethacin as a positive control group. Conclusion: The current study suggests that trehalose has a protective effect against arthritis, which may be mediated by antioxidative effects of this disaccharide.
AB - Background: The purpose of the present study was to study the potential anti-arthritic and antioxidant effects of trehalose in an experimental model of complete Freund’s adjuvant (CFA)-induced arthritis. Methods: Arthritis was induced via subcutaneous injection of CFA (0.1) into the right footpad of each rat. Trehalose (10 mg/kg per day) and indomethacin (5 mg/kg) as a reference drug were in-traperitoneally injected into CFA-induced arthritic rats from days 0 to 21. Changes in paw volume, pain responses, arthritic score, and oxidative/antioxidative parameters were determined. Results: Trehalose administration could significantly decrease arthritis scores (p <0.01) and paw edema (p <0.001), and significantly increase the nociceptive threshold (p <0.05) in CFA-induced arthritic rats. Trehalose also significantly reduced the pro-oxidant-antioxidant balance values when compared to CFA treatment alone. In addition, no significant difference was found between the trehalose group and indomethacin as a positive control group. Conclusion: The current study suggests that trehalose has a protective effect against arthritis, which may be mediated by antioxidative effects of this disaccharide.
KW - Antioxidant
KW - complete freund’s adjuvant (CFA)
KW - indomethacin
KW - oxidative stress
KW - rheumatoid arthritis
KW - trehalose
UR - http://www.scopus.com/inward/record.url?scp=85176315280&partnerID=8YFLogxK
U2 - 10.2174/2772270817666230825093141
DO - 10.2174/2772270817666230825093141
M3 - Article
C2 - 37622696
AN - SCOPUS:85176315280
SN - 2772-2708
VL - 17
SP - 145
EP - 151
JO - Recent Advances in Inflammation and Allergy Drug Discovery
JF - Recent Advances in Inflammation and Allergy Drug Discovery
IS - 2
ER -