Anthelmintic activity in plant secondary metabolites from Khaya senegalensis (African mahogany)

Suyog Subedi

Research output: ThesisDoctoral Thesis

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Abstract

Gastrointestinal worms in livestock production are becoming more problematic because the worms are developing resistance to medication, and consumers are concerned about drug residues in food. A possible solution is a tree, Khaya senegalensis, that seems to produce compounds that inhibit worm development. We fractionated extracts of leaf and bark and, in the laboratory, tested whether the fractions killed the larvae of Ascaris suum. We found strong activity in fractions containing linoleic and oleicacids, two limonoids (mahonin and methyl angolensate), and a completely novel limonoid, 16-oxodelevoyin B. We now have new options for managing livestock gut health.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Martin, Graeme, Supervisor
  • Vercoe, Phil, Supervisor
  • Payne, Stephanie, Supervisor
  • Durmic, Zoey, Supervisor
Thesis sponsors
Award date25 Aug 2022
DOIs
Publication statusUnpublished - 2022

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