Antenatal and postnatal influences on preterm diaphragm function

Christine Astell

Research output: Thesis › Doctoral Thesis

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Abstract

Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date24 Sep 2018
DOIs
Publication statusUnpublished - 2018

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Diaphragm
Artificial Respiration
Inflammation
Premature Infants
Respiratory Insufficiency
Dexamethasone
Glucocorticoids
Therapeutics

Cite this

Astell, Christine. / Antenatal and postnatal influences on preterm diaphragm function. 2018.
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Astell, C 2018, 'Antenatal and postnatal influences on preterm diaphragm function', Doctor of Philosophy, The University of Western Australia. https://doi.org/10.26182/5bee509e233b9

Antenatal and postnatal influences on preterm diaphragm function. / Astell, Christine.

2018.

Research output: Thesis › Doctoral Thesis

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AB - Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.

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Astell C. Antenatal and postnatal influences on preterm diaphragm function. 2018. https://doi.org/10.26182/5bee509e233b9

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  • THESIS - DOCTOR OF PHILOSOPHY - ASTELL Christine Jane - 2018

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