Antenatal and postnatal influences on preterm diaphragm function

Research output: ThesisDoctoral Thesis

20 Downloads (Pure)

Abstract

Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date24 Sep 2018
DOIs
Publication statusUnpublished - 2018

Fingerprint

Diaphragm
Artificial Respiration
Inflammation
Premature Infants
Respiratory Insufficiency
Dexamethasone
Glucocorticoids
Therapeutics

Cite this

@phdthesis{fbf56b978e2f4d6c85ead8211a05b852,
title = "Antenatal and postnatal influences on preterm diaphragm function",
abstract = "Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.",
keywords = "Diaphragm, Preterm birth, Work of breathing, Muscle weakness, Respiratory distress, Inflammation, Mechanical ventilation, Dexamethasone",
author = "Christine Astell",
year = "2018",
doi = "10.26182/5bee509e233b9",
language = "English",
school = "The University of Western Australia",

}

TY - THES

T1 - Antenatal and postnatal influences on preterm diaphragm function

AU - Astell, Christine

PY - 2018

Y1 - 2018

N2 - Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.

AB - Impaired diaphragm development likely contributes to respiratory insufficiencies in preterm infants. This thesis addresses the impact of perinatal inflammation, glucocorticoid therapy, and mechanical ventilation, on preterm diaphragm function during early postnatal life, using preterm lamb and newborn rat models. These studies suggest that the duration of mechanical ventilation is the most significant predictor of preterm diaphragm function; that in utero inflammation increases dependance on mechanical ventilation; and accelerated weaning from mechanical ventilation with dexamethasone benefits preterm diaphragm function. Diaphragm function should be considered when treating preterm respiratory disease.

KW - Diaphragm

KW - Preterm birth

KW - Work of breathing

KW - Muscle weakness

KW - Respiratory distress

KW - Inflammation

KW - Mechanical ventilation

KW - Dexamethasone

U2 - 10.26182/5bee509e233b9

DO - 10.26182/5bee509e233b9

M3 - Doctoral Thesis

ER -